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Formation and abundance of 5-hydroxymethylcytosine in RNA.
Huber, Sabrina M; van Delft, Pieter; Mendil, Lee; Bachman, Martin; Smollett, Katherine; Werner, Finn; Miska, Eric A; Balasubramanian, Shankar.
Afiliación
  • Huber SM; University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW (UK).
Chembiochem ; 16(5): 752-5, 2015 Mar 23.
Article en En | MEDLINE | ID: mdl-25676849
RNA methylation is emerging as a regulatory RNA modification that could have important roles in the control and coordination of gene transcription and protein translation. Herein, we describe an in vivo isotope-tracing methodology to demonstrate that the ribonucleoside 5-methylcytidine (m(5)C) is subject to oxidative processing in mammals, forming 5-hydroxymethylcytidine (hm(5)C) and 5-formylcytidine (f(5)C). Furthermore, we have identified hm(5)C in total RNA from all three domains of life and in polyA-enriched RNA fractions from mammalian cells. This suggests m(5)C oxidation is a conserved process that could have critical regulatory functions inside cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Citosina Límite: Animals Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Citosina Límite: Animals Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Alemania