Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed.
Neuroreport
; 26(4): 186-91, 2015 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-25674902
Acetylcholine influences the speed of information processing. We examined the effect of the rs3841324 polymorphism (L/S) and the rs16969968 (G/A) polymorphism on response speed in the Stroop task and the Negative priming task. These polymorphisms are located in the gene that encodes the nicotinic acetylcholine receptor α5-subunit (CHRNA5). Male carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were faster than male carriers of at least one L allele or one A allele. In contrast, female carriers of the rs3841324 S/S genotype and the rs16969968 G/G genotype were slower than female carriers of at least one L allele or one A allele. These results indicate that the minor alleles of both polymorphisms modulate response speed in a sex-dependent, diametrically opposed manner.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiempo de Reacción
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Receptores Nicotínicos
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Polimorfismo de Nucleótido Simple
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Test de Stroop
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Proteínas del Tejido Nervioso
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Reino Unido