Testosterone induces apoptosis in cardiomyocytes by increasing proapoptotic signaling involving tumor necrosis factor-&#945; and renin angiotensin system.

do Nascimento, A M; de Lima, E M; Boëchat, G A P; Meyrelles, S D S; Bissoli, N S; Lenz, D; Endringer, D C; de Andrade, T U

Testosterone induces apoptosis in cardiomyocytes by increasing proapoptotic signaling involving tumor necrosis factor-α and renin angiotensin system.

do Nascimento, A M; de Lima, E M; Boëchat, G A P; Meyrelles, S D S; Bissoli, N S; Lenz, D; Endringer, D C; de Andrade, T U.

Afiliación

do Nascimento AM; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil.
de Lima EM; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil.
Boëchat GA; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil.
Meyrelles SD; Department of Physiological Sciences, Federal University of Espírito Santo, Espírito Santo, Brazil.
Bissoli NS; Department of Physiological Sciences, Federal University of Espírito Santo, Espírito Santo, Brazil.
Lenz D; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil.
Endringer DC; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil.
de Andrade TU; Department of Pharmacy, University Vila Velha, Espírito Santo, Brazil tadeu.andrade@uvv.br.

Hum Exp Toxicol ; 34(11): 1139-47, 2015 Nov.

Article en En | MEDLINE | ID: mdl-25673179

Asunto(s)

Miocitos Cardíacos/efectos de los fármacos; Peptidil-Dipeptidasa A/metabolismo; Testosterona/farmacología; Factor de Necrosis Tumoral alfa/metabolismo; Animales; Apoptosis/efectos de los fármacos; Caspasa 3/metabolismo; Línea Celular; Miocitos Cardíacos/metabolismo; Ratas; Sistema Renina-Angiotensina/efectos de los fármacos; Transducción de Señal/efectos de los fármacos

Palabras clave

ACE; Anabolic agents; H9c2; TNF-α; apoptosis; caspase-3

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Testosterona / Factor de Necrosis Tumoral alfa / Peptidil-Dipeptidasa A / Miocitos Cardíacos Límite: Animals Idioma: En Revista: Hum Exp Toxicol Asunto de la revista: TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

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