A case of multiple endocrine neoplasia (MEN) type 1; the immunohistochemical and ultrastructural studies of its tumors and the analysis of hormones in tumor extracts.
Endocrinol Jpn
; 36(1): 37-45, 1989 Feb.
Article
en En
| MEDLINE
| ID: mdl-2567230
We reported a case of sporadic multiple endocrine neoplasia type 1, with multiple insulinoma, parathyroid adenoma, and pituitary tumor. Measurement of hormone contents and immunohistochemical studies of the pancreatic tumors showed that the tumors contained insulin, glucagon, somatostatin, and pancreatic polypeptide. Furthermore, the concentrations of these hormones were different in each tumor. Insulin extracted from the pancreatic tumors analyzed by reversed-phase high performance liquid chromatography revealed no structural abnormalities. On the other hand, in gel filtration evaluation of the extract of the parathyroid adenoma, it was found that the tumor extract contained a macromolecular parathyroid hormone (molecular weight 20,000 to 25,000).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pancreáticas
/
Neoplasias de las Paratiroides
/
Neoplasias Hipofisarias
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Neoplasia Endocrina Múltiple
/
Adenoma
/
Adenoma de Células de los Islotes Pancreáticos
/
Insulinoma
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Endocrinol Jpn
Año:
1989
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón