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Minor secondary metabolites from the bark of Entandrophragma congoënse (Meliaceae).
Happi, Gervais Mouthé; Kouam, Simeon Fogue; Talontsi, Ferdinand Mouafo; Zühlke, Sebastian; Lamshöft, Marc; Spiteller, Michael.
Afiliación
  • Happi GM; Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6,
  • Kouam SF; Department of Chemistry, Higher Teachers' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon. Electronic address: kfogue@yahoo.com.
  • Talontsi FM; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
  • Zühlke S; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
  • Lamshöft M; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
  • Spiteller M; Institute of Environmental Research (INFU) of the Faculty of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
Fitoterapia ; 102: 35-40, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25665944
Two new tirucallane-type triterpenoids were isolated from the bark of Entandrophragma congoënse (Meliaceae) along with five known compounds gladoral A, bipendensin, 4-hydroxymethyl-3,5-dimethyldihydrofuran-2(3H)-one, scopoletin and 5,7-dimethoxy-6-hydroxycoumarin. Their structures were elucidated by means of spectroscopic analyses including 1D and 2D-NMR spectroscopy, high resolution mass spectrometric data as well as the comparison of data with those reported in the literature. The tested compounds (1-4) displayed moderated antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum strain NF54 and low cytotoxicity on L6 cell lines. All the isolated compounds are reported for the first time from the genus Entandrophragma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Meliaceae / Corteza de la Planta Límite: Animals Idioma: En Revista: Fitoterapia Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Meliaceae / Corteza de la Planta Límite: Animals Idioma: En Revista: Fitoterapia Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos