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Lactobacillus paracasei F19 versus placebo for the prevention of proton pump inhibitor-induced bowel symptoms: a randomized clinical trial.
Compare, Debora; Rocco, Alba; Sgamato, Costantino; Coccoli, Pietro; Campo, Salvatore Maria Antonio; Nazionale, Immacolata; Larussa, Tiziana; Luzza, Francesco; Chiodini, Paolo; Nardone, Gerardo.
Afiliación
  • Compare D; Department of Clinical Medicine and Surgery, Gastroenterology Unit, University Federico II, Naples, Italy.
  • Rocco A; Department of Clinical Medicine and Surgery, Gastroenterology Unit, University Federico II, Naples, Italy.
  • Sgamato C; Department of Clinical Medicine and Surgery, Gastroenterology Unit, University Federico II, Naples, Italy.
  • Coccoli P; Department of Clinical Medicine and Surgery, Gastroenterology Unit, University Federico II, Naples, Italy.
  • Campo SM; Gastroenterology Unit, Nuovo Regina Margherita Hospital, Rome, Italy.
  • Nazionale I; Department of Health Science, University Magna Graecia, Catanzaro, Italy.
  • Larussa T; Department of Health Science, University Magna Graecia, Catanzaro, Italy.
  • Luzza F; Department of Health Science, University Magna Graecia, Catanzaro, Italy.
  • Chiodini P; Medical Statistics Unit, Second University of Naples, Complesso Didattico di S. Patrizia, Naples, Italy.
  • Nardone G; Department of Clinical Medicine and Surgery, Gastroenterology Unit, University Federico II, Naples, Italy. Electronic address: nardone@unina.it.
Dig Liver Dis ; 47(4): 273-9, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25660822
BACKGROUND: Proton pump inhibitors may foster intestinal dysbiosis and related bowel symptoms. AIM: To evaluate the effect of Lactobacillus paracasei F19 on bowel symptom onset in patients on long-term proton pump inhibitors. METHODS: In this randomized, double-blind, placebo-controlled study, patients with typical gastroesophageal reflux disease symptoms receiving pantoprazole 40 mg/d for six months were randomly assigned to receive: (A) Lactobacillus paracasei F19 bid for three days/week for six months; (B) placebo bid for three days/week for six months; (C) Lactobacillus paracasei F19 bid for three days/week for three months and placebo bid for three days/week for the following three months; (D) placebo bid for three days/week for three months and Lactobacillus paracasei F19 bid for three days/week for the following three months. Bloating, flatulence, abdominal pain and bowel habit were assessed monthly. RESULTS: 100/312 patients were enrolled. In the parallel groups, the treatment-by-time interaction affected bloating (p = 0.015), while Lactobacillus paracasei F19 treatment alone affected flatulence (p = 0.011). Moreover, the treatment-by-time interaction significantly affected the mean score of bloating (p = 0.01) and flatulence (p < 0.0001), the mean stool form (p = 0.03) and mean stool frequency/week (p = 0.016). Analysis of the cross-over groups, limited to the first three months because of carry-over effect, confirmed these results. CONCLUSION: Lactobacillus paracasei F19 supplementation prevents bowel symptom onset in patients on long-term proton pump inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Suplementos Dietéticos / Síndrome del Colon Irritable / Inhibidores de la Bomba de Protones / Lactobacillus Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Probióticos / Suplementos Dietéticos / Síndrome del Colon Irritable / Inhibidores de la Bomba de Protones / Lactobacillus Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dig Liver Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos