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Discoidin domain receptors (DDRs): potential implications in atherosclerosis.
Ju, Gui-Xia; Hu, Ying-Bin; Du, Mei-Rong; Jiang, Jun-Lin.
Afiliación
  • Ju GX; Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
  • Hu YB; Department of Colorectal Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
  • Du MR; Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
  • Jiang JL; Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China. Electronic address: junlinjiang@csu.edu.cn.
Eur J Pharmacol ; 751: 28-33, 2015 Mar 15.
Article en En | MEDLINE | ID: mdl-25657115
Atherosclerosis, one of the most common causes of cardiovascular diseases, is associated with a high morbidity and mortality. It is known that inflammation, vascular smooth muscle cell (VSMCs) phenotypic modulation and atheroma plaque vulnerability are main pathological characteristics of atherosclerosis. The discoidin domain receptors (DDRs), as unique collagen-binding tyrosine kinase receptors, were reported to be involved in the above pathogenesis process of atherogenesis. DDRs were detected on a series of cells within atherosclerotic plaques including macrophages, T cells and smooth muscle cells, and regulated the behaviors of these cells, implicating the potential involvement of DDRs in atherosclerosis. Herein we discuss the roles of DDRs in atherosclerosis, in an attempt to evaluate the value of DDRs as a therapeutic target for atherosclerosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Mitogénicos / Proteínas Tirosina Quinasas Receptoras / Aterosclerosis Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Mitogénicos / Proteínas Tirosina Quinasas Receptoras / Aterosclerosis Límite: Humans Idioma: En Revista: Eur J Pharmacol Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos