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Quantitative variability of 342 plasma proteins in a human twin population.
Liu, Yansheng; Buil, Alfonso; Collins, Ben C; Gillet, Ludovic C J; Blum, Lorenz C; Cheng, Lin-Yang; Vitek, Olga; Mouritsen, Jeppe; Lachance, Genevieve; Spector, Tim D; Dermitzakis, Emmanouil T; Aebersold, Ruedi.
Afiliación
  • Liu Y; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland liu@imsb.biol.ethz.ch aebersold@imsb.biol.ethz.ch.
  • Buil A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Collins BC; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Gillet LC; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Blum LC; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Cheng LY; Department of Statistics and Department of Computer Science, Purdue University, West Lafayette, IN, USA.
  • Vitek O; Department of Statistics and Department of Computer Science, Purdue University, West Lafayette, IN, USA.
  • Mouritsen J; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
  • Lachance G; Department of Twin Research and Genetic Epidemiology, King's College London St Tomas' Hospital Campus, London, UK.
  • Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London St Tomas' Hospital Campus, London, UK.
  • Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland Faculty of Science, University of Zurich, Zurich, Switzerland liu@imsb.biol.ethz.ch aebersold@imsb.biol.ethz.ch.
Mol Syst Biol ; 11(1): 786, 2015 Feb 04.
Article en En | MEDLINE | ID: mdl-25652787
The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different traits in human population, we applied here the highly accurate and reproducible SWATH mass spectrometry technique to quantify 1,904 peptides defining 342 unique plasma proteins in 232 plasma samples collected longitudinally from pairs of monozygotic and dizygotic twins at intervals of 2-7 years, and proportioned the observed total quantitative variability to its root causes, genes, and environmental and longitudinal factors. The data indicate that different proteins show vastly different patterns of abundance variability among humans and that genetic control and longitudinal variation affect protein levels and biological processes to different degrees. The data further strongly suggest that the plasma concentrations of clinical biomarkers need to be calibrated against genetic and temporal factors. Moreover, we identified 13 cis-SNPs significantly influencing the level of specific plasma proteins. These results therefore have immediate implications for the effective design of blood-based biomarker studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Polimorfismo de Nucleótido Simple Tipo de estudio: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Mol Syst Biol Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Polimorfismo de Nucleótido Simple Tipo de estudio: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Mol Syst Biol Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido