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The association between subjective and objective parameters for the assessment of dry-eye syndrome.
Schmidl, Doreen; Witkowska, Katarzyna Jadwiga; Kaya, Semira; Baar, Carina; Faatz, Henrik; Nepp, Johannes; Unterhuber, Angelika; Werkmeister, René Marcel; Garhofer, Gerhard; Schmetterer, Leopold.
Afiliación
  • Schmidl D; Department of Clinical Pharmacology, Medical University of Vienna, Austria Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
  • Witkowska KJ; Department of Clinical Pharmacology, Medical University of Vienna, Austria.
  • Kaya S; Department of Ophthalmology, Paracelsus Medical University, Salzburg, Austria.
  • Baar C; Department of Clinical Pharmacology, Medical University of Vienna, Austria.
  • Faatz H; Department of Clinical Pharmacology, Medical University of Vienna, Austria.
  • Nepp J; Department of Ophthalmology and Optometry, Medical University of Vienna, Austria.
  • Unterhuber A; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
  • Werkmeister RM; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
  • Garhofer G; Department of Clinical Pharmacology, Medical University of Vienna, Austria.
  • Schmetterer L; Department of Clinical Pharmacology, Medical University of Vienna, Austria Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Invest Ophthalmol Vis Sci ; 56(3): 1467-72, 2015 Feb 03.
Article en En | MEDLINE | ID: mdl-25650419
PURPOSE: The aim of the present study was to evaluate the association between symptoms and different clinical signs in patients with dry-eye syndrome (DES). METHODS: Fifty-two patients with DES were included in the present cross-sectional study. For assessment of symptoms, the Ocular Surface Disease Index (OSDI) was used. Clinical parameters included measurement of tear break up time (BUT), corneal fluorescein staining, tear osmolarity, and ocular scattering index (OSI). Tear film thickness (TFT) was assessed using a custom-built optical coherence tomography (OCT) system with an axial resolution of 1.2 µm. In addition, impression cytology was performed. Correlation coefficients were calculated using linear regression analysis. RESULTS: The mean OSDI in the present study population was 28.9 ± 17.6, the mean TFT was 4.1 ± 1.3 µm. A significant negative correlation was found between OSDI and TFT (r = -0.34, P = 0.01). Tear film thickness correlated positively with BUT (r = 0.35, P = 0.01), but with no other signs of DES. No association was found between OSDI and the other evaluated signs. CONCLUSIONS: The study population mainly comprised of patients with mild to moderate DES. Tear film thickness as measured with a custom-built OCT device correlated with subjective symptoms in these patients. In agreement with previous data, the association between other signs and symptoms was weak in the present study. Measurement of TFT with OCT may become a valuable tool in the management of DES patients. (ClinicalTrials.gov number, NCT01753687.)
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de Ojo Seco Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de Ojo Seco Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Invest Ophthalmol Vis Sci Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos