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The effects of single hemodialysis session on arterial stiffness in hemodialysis patients.
Ögünç, Handan; Akdam, Hakan; Alp, Alper; Gencer, Fatih; Akar, Harun; Yeniçerioglu, Yavuz.
Afiliación
  • Ögünç H; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
  • Akdam H; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
  • Alp A; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
  • Gencer F; Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
  • Akar H; Department of Internal Medicine Yenisehir, Tepecik Training and Research Hospital, Izmir, Turkey.
  • Yeniçerioglu Y; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.
Hemodial Int ; 19(3): 463-71, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25650022
Increased arterial stiffness in hemodialysis patients is a strong predictor of cardiovascular morbidity and mortality. Pulse wave velocity (PWV) and augmentation index (AIx), which are markers of arterial stiffness, were used to determine the severity of vascular damage noninvasively. This study aimed to investigate the effects of solute volume removal and hemodynamic changes on PWV and AIx of a single hemodialysis session. Thirty hemodialysis patients were enrolled in the study. Before initiation of hemodialysis, every 15 minutes during hemodialysis, and 30 minutes after the completion of the session, measurements of PWV and AIx@75 (normalized with heart rate 75 bpm) were obtained from each patient. Body composition was analyzed by bioimpedance spectroscopy device before and 30 minutes after completion of the hemodialysis session. During the hemodialysis, no significant change was observed in AIx@75. However, PWV decreased steadily during the session reaching statistically significant level at 135th minute (P = 0.026), with a maximal drop at 210th minute (P < 0.001). At 210th minute, decrease in PWV correlated positively with the decrease in central systolic blood pressure, central diastolic blood pressure, central pulse pressure, augmentation pressure, and AIx@75. Multiple regression analysis showed that decrease in PWV at 210th minute was associated with decrease in central systolic blood pressure and central pulse pressure. Ultrafiltration during hemodialysis had no significant effect on PWV and AIx@75. Delta urea correlated positively with delta PWV at 240th minute. A significant decrease in PWV was observed during hemodialysis and correlated with urea reduction; however, we were unable to document any effect of volume removal on arterial stiffness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Impedancia Eléctrica / Rigidez Vascular / Análisis de la Onda del Pulso Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Hemodial Int Asunto de la revista: NEFROLOGIA / TERAPEUTICA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Impedancia Eléctrica / Rigidez Vascular / Análisis de la Onda del Pulso Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Hemodial Int Asunto de la revista: NEFROLOGIA / TERAPEUTICA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Canadá