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The natural history of genital human papillomavirus among HIV-negative men having sex with men and men having sex with women.
Nyitray, Alan G; Chang, Mihyun; Villa, Luisa L; Carvalho da Silva, Roberto J; Baggio, Maria Luiza; Abrahamsen, Martha; Papenfuss, Mary; Quiterio, Manuel; Salmerón, Jorge; Lazcano-Ponce, Eduardo; Giuliano, Anna R.
Afiliación
  • Nyitray AG; The University of Texas School of Public Health at Houston, Texas.
  • Chang M; The University of Texas School of Public Health at Houston, Texas.
  • Villa LL; School of Medicine, University of São Paulo, School of Medical Sciences, Santa Casa de São Paulo.
  • Carvalho da Silva RJ; Centro de Referência e Treinamento em DST/AIDS.
  • Baggio ML; Center of Translational Oncology, Instituto do Câncer do Estado de São Paulo-ICESP, Brazil.
  • Abrahamsen M; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Papenfuss M; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  • Quiterio M; Instituto Nacional de Salud Pública.
  • Salmerón J; Instituto Nacional de Salud Pública Instituto Mexicano del Seguro Social.
  • Lazcano-Ponce E; Instituto Nacional de Salud Pública, Cuernavaca, Mexico.
  • Giuliano AR; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
J Infect Dis ; 212(2): 202-12, 2015 Jul 15.
Article en En | MEDLINE | ID: mdl-25649172
BACKGROUND: Although human immunodeficiency virus (HIV)-negative men having sex with men (MSM) bear a substantial burden of human papillomavirus (HPV)-associated disease, prospective studies of genital HPV infection in this population are scarce. METHODS: HPV genotyping was conducted on genital samples from men (aged 18-70 years) from Brazil, Mexico, or the United States who provided specimens at 6-month intervals for up to 4 years. Eligibility criteria included no history of genital warts or HIV infection. Evaluable specimens were collected from 564 MSM and 3029 men having sex with women (MSW). Incidence and clearance estimates with 95% confidence intervals were calculated. RESULTS: The 12-month cumulative incidence of genital HPV was high in both MSM (25%; 95% confidence interval, 21%-30%) and MSW (21%; 20%-23%). After stratifying by city, MSM and MSW incidence rates were comparable, with 3 exceptions where MSM had higher incidence in ≥1 city: the group of quadrivalent vaccine types, HPV-45, and HPV-11. Median times to HPV-16 clearance were also comparable, with point estimates of >6 months for both MSM and MSW. CONCLUSIONS: Unlike with many other sexually transmitted infections, genital HPV natural history may be similar in HIV-negative MSM and MSW. Study periods of ≤6 months, however, may not be long enough to accurately measure the persistence of these infections in men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Virales de Transmisión Sexual / Infecciones por Papillomavirus Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Virales de Transmisión Sexual / Infecciones por Papillomavirus Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos