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Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.
Hendricks, Gabriel L; Velazquez, Lourdes; Pham, Serena; Qaisar, Natasha; Delaney, James C; Viswanathan, Karthik; Albers, Leila; Comolli, James C; Shriver, Zachary; Knipe, David M; Kurt-Jones, Evelyn A; Fygenson, Deborah K; Trevejo, Jose M; Wang, Jennifer P; Finberg, Robert W.
Afiliación
  • Hendricks GL; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
  • Velazquez L; Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93106, United States.
  • Pham S; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
  • Qaisar N; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
  • Delaney JC; Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
  • Viswanathan K; Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
  • Albers L; Charles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
  • Comolli JC; Charles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
  • Shriver Z; Department of Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, United States.
  • Knipe DM; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
  • Kurt-Jones EA; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
  • Fygenson DK; Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93106, United States.
  • Trevejo JM; Charles Stark Draper Laboratory, Department of Bioengineering, 555 Technology Square, Cambridge, MA 02139, United States.
  • Wang JP; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
  • Finberg RW; Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States.
Antiviral Res ; 116: 34-44, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25637710
Heparan sulfate (HS) is a ubiquitous glycosaminoglycan that serves as a cellular attachment site for a number of significant human pathogens, including respiratory syncytial virus (RSV), human parainfluenza virus 3 (hPIV3), and herpes simplex virus (HSV). Decoy receptors can target pathogens by binding to the receptor pocket on viral attachment proteins, acting as 'molecular sinks' and preventing the pathogen from binding to susceptible host cells. Decoy receptors functionalized with HS could bind to pathogens and prevent infection, so we generated decoy liposomes displaying HS-octasaccharide (HS-octa). These decoy liposomes significantly inhibited RSV, hPIV3, and HSV infectivity in vitro to a greater degree than the original HS-octa building block. The degree of inhibition correlated with the density of HS-octa displayed on the liposome surface. Decoy liposomes with HS-octa inhibited infection of viruses to a greater extent than either full-length heparin or HS-octa alone. Decoy liposomes were effective when added prior to infection or following the initial infection of cells in vitro. By targeting the well-conserved receptor-binding sites of HS-binding viruses, decoy liposomes functionalized with HS-octa are a promising therapeutic antiviral agent and illustrate the utility of the liposome delivery platform.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Virus Sincitiales Respiratorios / Replicación Viral / Simplexvirus / Virus de la Parainfluenza 3 Humana / Heparitina Sulfato / Liposomas Límite: Animals Idioma: En Revista: Antiviral Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Virus Sincitiales Respiratorios / Replicación Viral / Simplexvirus / Virus de la Parainfluenza 3 Humana / Heparitina Sulfato / Liposomas Límite: Animals Idioma: En Revista: Antiviral Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos