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Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma.
Ma, Chao; Peng, Chunyan; Lu, Xuejia; Ding, Xiwei; Zhang, Shu; Zou, Xiaoping; Zhang, Xiaoqi.
Afiliación
  • Ma C; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
  • Peng C; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
  • Lu X; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
  • Ding X; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
  • Zhang S; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China.
  • Zou X; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China. Electronic address: 13770771661@163.com.
  • Zhang X; The Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu Province 210008, PR China. Electronic address: zhangxiaoqinj@163.com.
Biochem Biophys Res Commun ; 458(2): 234-9, 2015 Mar 06.
Article en En | MEDLINE | ID: mdl-25623530
FOXP3 is known as a master control of regulatory T cells with recently studies indicating its expression in several tumor cells. In order to study the precise role of FOXP3 in cholangiocarcinoma, FOXP3 was knocked down in cholangiocarcinoma cell lines. Down regulation of FOXP3 inhibits tumor cell invasion by reducing the quantity of MMP-9 and MMP-2. With FOXP3 knocking down, IL-10 and TGF-ß1 secreted by cancer cells diminishes and the cell survival of T cells is significant up-regulation. These results suggest that FOXP3 plays an important role in tumor malignant phenotype, especially the invasion and immune escape.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Conductos Biliares Intrahepáticos / Colangiocarcinoma / Escape del Tumor / Factores de Transcripción Forkhead Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Conductos Biliares Intrahepáticos / Colangiocarcinoma / Escape del Tumor / Factores de Transcripción Forkhead Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Biochem Biophys Res Commun Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos