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Validation of the neutrophil-to-lymphocyte ratio as a prognostic factor in a cohort of European prostate cancer patients.
Langsenlehner, Tanja; Thurner, Eva-Maria; Krenn-Pilko, Sabine; Langsenlehner, Uwe; Stojakovic, Tatjana; Gerger, Armin; Pichler, Martin.
Afiliación
  • Langsenlehner T; Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria. tanja.langsenlehner@medunigraz.at.
  • Thurner EM; Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria.
  • Krenn-Pilko S; Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria.
  • Langsenlehner U; Division of Internal Medicine, Outpatient Department Graz, Graz, Austria.
  • Stojakovic T; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Comprehensive Cancer Center Graz, Medical University of Graz, Graz, Austria.
  • Gerger A; Division of Clinical Oncology, Department of Medicine, Comprehensive Cancer Center, Medical University of Graz, Graz, Austria.
  • Pichler M; Division of Clinical Oncology, Department of Medicine, Comprehensive Cancer Center, Medical University of Graz, Graz, Austria.
World J Urol ; 33(11): 1661-7, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25617235
PURPOSE: Recent studies have expanded the concept that the systemic inflammatory response has an important role in the progression of several solid tumors. The neutrophil-to-lymphocyte ratio (NLR), an easily determinable marker of systemic inflammation, has been associated with clinical outcome in various cancer entities. In the present study, we validated the prognostic relevance of an elevated NLR in a cohort of European prostate cancer patients. METHODS: Data from 415 consecutive prostate cancer patients treated with 3D conformal radiotherapy at a single tertiary academic center from 1999 to 2007 were included in this retrospective study. Clinical progression-free survival (PFS), distant metastases-free survival (DMFS), and overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the prognostic relevance, univariate and multivariate Cox regression models were performed for each end point. RESULTS: Based on previously published studies, an NLR ≥ 5 was selected as cutoff value for external validation. Multivariate analysis identified an increased NLR as an independent prognostic factor for clinical PFS [hazard ratio (HR) 3.09, 95 % CI 1.64-5.82, p < 0.001], DMFS (HR 3.51, 95 % CI 1.80-6.85, p < 0.001), and OS (HR 2.16, 95 % CI 1.17-3.99, p = 0.013). CONCLUSION: The NLR seems to represent an independent prognostic marker and should be considered for future individual risk assessment in patients with prostate cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Linfocitos / Neutrófilos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: World J Urol Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Linfocitos / Neutrófilos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Humans / Male País/Región como asunto: Europa Idioma: En Revista: World J Urol Año: 2015 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Alemania