A competing risks approach to "biologic" interaction.
Lifetime Data Anal
; 21(2): 300-14, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25613424
In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Modificador del Efecto Epidemiológico
/
Modelos de Riesgos Proporcionales
/
Biometría
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Lifetime Data Anal
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Estados Unidos