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Genotoxic effects of prenatal exposure to levetiracetam during pregnancy on rat offsprings.
Tural, Sengul; Tekcan, Akin; Elbistan, Mehmet; Karakus, Nevin; Ozyurek, Hamit; Kara, Nurten.
Afiliación
  • Tural S; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey stural@omu.edu.tr.
  • Tekcan A; School of Health, Ahi Evran University, Kirsehir, Turkey.
  • Elbistan M; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Karakus N; Department of Medical Biology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
  • Ozyurek H; Department of Pediatric Neurology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Kara N; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
In Vivo ; 29(1): 77-81, 2015.
Article en En | MEDLINE | ID: mdl-25600534
Levetiracetam is a new-generation antiepileptic drug initially approved as an adjunctive treatment for patients with refractory partial seizures and is now also used as a monotherapy. The aim of this study was to evaluate the genotoxic effects of levetiracetam exposure during pregnancy on rat offsprings. In this study, we used the newborn pups of rats exposed to levetiracetam during pregnancy. Thirty Sprague-Dawley rats were divided into three groups. The mother rats of groups 1 and 2 were treated with different doses of levetiracetam (25 mg/kg/d and 50 mg/kg/d) from gestational days 1 to 18 during pregnancy. Group 3 (control group) was not treated with any drug. In vivo sister chromatid exchange (SCE) induction and in vivo micronucleus formation were assessed. Bone marrow from rat pups were used for investigation. As a result of this study, levetiracetam exposure did not alter SCE frequencies or the mean of number of micronuclei in the prenatal period (p>0.05). Levetiracetam did not cause miscarriage during pregnancy in mother rats. The present study highlighted fetal safety after prenatal exposure to levetiracetam.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piracetam / Efectos Tardíos de la Exposición Prenatal / Exposición Materna / Anticonvulsivantes / Mutágenos Límite: Animals / Pregnancy Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Grecia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piracetam / Efectos Tardíos de la Exposición Prenatal / Exposición Materna / Anticonvulsivantes / Mutágenos Límite: Animals / Pregnancy Idioma: En Revista: In Vivo Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Grecia