Your browser doesn't support javascript.
loading
Specific association of IL17A genetic variants with panuveitis.
Mucientes, Arkaitz; Márquez, Ana; Cordero-Coma, Miguel; Martín-Villa, José Manuel; Gorroño-Echebarría, Marina Begoña; Blanco, Ricardo; Díaz Valle, David; Benítez-del-Castillo, José Manuel; del Rio, María José; Blanco, Ana; Olea, Jose Luis; Cordero, Yolanda; Capella, María José; Gonzalez, Jacobo; Díaz-Llopis, Manuel; Ortego-Centeno, Norberto; Adán, Alfredo; Ruiz-Arruza, Ioana; Llorenç, Víctor; Fonollosa, Alejandro; Martín, Javier.
Afiliación
  • Mucientes A; Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.
  • Márquez A; Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain.
  • Cordero-Coma M; Ophthalmology Department, Hospital de León, IBIOMED, Universidad de León, León, Spain.
  • Martín-Villa JM; Immunology Department, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
  • Gorroño-Echebarría MB; Ophthalmology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, Spain.
  • Blanco R; Rheumatology Department, Hospital Marqués de Valdecilla, IDIVAL, Santander, Spain.
  • Díaz Valle D; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • Benítez-del-Castillo JM; Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain.
  • del Rio MJ; Ophthalmology Department, Hospital Carlos Haya, Málaga, Spain.
  • Blanco A; Ophthalmology Department, Hospital Donostia, San Sebastián (Guipúzcoa), Spain.
  • Olea JL; Ophthalmology Department, Hospital Son Espases, Palma de Mallorca, Spain.
  • Cordero Y; Ophthalmology Department, Hospital Universitario Rio Hortega, Valladolid, Spain.
  • Capella MJ; Institut Universitari Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Gonzalez J; Ophthalmology Department, Hospital de la Princesa, Madrid, Spain.
  • Díaz-Llopis M; Ophthalmology Department, Hospital La Fe, Universidad de Valencia, Valencia, Spain.
  • Ortego-Centeno N; Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain.
  • Adán A; Ophthalmology Department, Hospital Clinic, Barcelona, Spain.
  • Ruiz-Arruza I; Autoimmune Diseases Research Unit, Internal Medicine Department, BioCruces Health Research Institute, Hospital Universitario Cruces, Barakaldo, Spain.
  • Llorenç V; Ophthalmology Department, Hospital Clinic, Barcelona, Spain.
  • Fonollosa A; Ophthalmology Department, BioCruces Health Research Institute, Hospital Universitario Cruces, Barakaldo, Spain.
  • Martín J; Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain.
Br J Ophthalmol ; 99(4): 566-70, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25595174
BACKGROUND/AIMS: A pathogenic role of Th17 cells in uveitis has become clear in recent years. Therefore, in the present study, we aimed to evaluate the possible influence of the IL17A locus on susceptibility to non-anterior uveitis and its main clinical subgroups. METHODS: Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909), selected by tagging, were genotyped using TaqMan assays in 353 Spanish patients with non-anterior uveitis and 1851 ethnically matched controls. RESULTS: The case/control analysis yielded a consistent association between two of the analysed genetic variants, rs8193036 and rs2275913, and the presence of panuveitis under a dominant model (pFDR=2.86E-03, OR=2.26, 95% CI 1.42 to 3.59 and pFDR=0.033, OR=1.83, 95% CI 1.13 to 2.97, respectively). Subsequently, a specific association of both polymorphisms with the diffuse form of the disease was evident in the subphenotype analysis when considering this same genetic model (panuveitis vs posterior and intermediate uveitis: rs8193036, p=0.020; rs2275913, p=0.038). Independent effects of rs8193036 and rs2275913 were observed by conditional regression analysis. CONCLUSIONS: Polymorphisms within the IL17A locus show a novel association with panuveitis. Our data agree with the elevated levels of this cytokine that are found in patients with uveitis, supporting a crucial role of Th17 cells in this pathology. SUBTITLE: Our results clearly evidenced the role of IL17A as a novel genetic risk factor for panuveitis, thus suggesting the implication of Th17 cells in the extensive inflammation of the uveal tract that occurs in this subtype of uveitis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panuveítis / Predisposición Genética a la Enfermedad / Interleucina-17 / Polimorfismo de Nucleótido Simple Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Ophthalmol Año: 2015 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Panuveítis / Predisposición Genética a la Enfermedad / Interleucina-17 / Polimorfismo de Nucleótido Simple Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Ophthalmol Año: 2015 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido