Pharmacological lineage analysis revealed the binding affinity of broad-spectrum substance P antagonists to receptors for gonadotropin-releasing peptide.

Arai, Kazune; Kashiwazaki, Aki; Fujiwara, Yoko; Tsuchiya, Hiroyoshi; Sakai, Nobuya; Shibata, Katsushi; Koshimizu, Taka-aki

Arai, Kazune; Kashiwazaki, Aki; Fujiwara, Yoko; Tsuchiya, Hiroyoshi; Sakai, Nobuya; Shibata, Katsushi; Koshimizu, Taka-aki.

Afiliación

Arai K; Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
Kashiwazaki A; Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
Fujiwara Y; Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
Tsuchiya H; Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan.
Sakai N; Department of Functional Genomics, Graduate School of Pharmaceutical Sciences, Himeji Dokkyo University, Hyogo 670-8524, Japan.
Shibata K; Department of Functional Genomics, Graduate School of Pharmaceutical Sciences, Himeji Dokkyo University, Hyogo 670-8524, Japan.
Koshimizu TA; Division of Molecular Pharmacology, Department of Pharmacology, Jichi Medical University, Tochigi 329-0498, Japan. Electronic address: t_koshi@jichi.ac.jp.

Eur J Pharmacol ; 749: 98-106, 2015 Feb 15.

Article en En | MEDLINE | ID: mdl-25592317

Asunto(s)

Receptores de Oxitocina/metabolismo; Receptores de Vasopresinas/metabolismo; Sustancia P/antagonistas & inhibidores; Secuencia de Aminoácidos; Animales; Células CHO; Cricetinae; Cricetulus; Hormona Liberadora de Gonadotropina/metabolismo; Péptidos/metabolismo; Receptores de Oxitocina/química; Receptores de Vasopresinas/química; Homología de Secuencia; Sustancia P/análogos & derivados

Palabras clave

Arginine vasopressin (PubChem CID: 644077); Broad-spectrum antagonists; Gonadotropin-releasing hormone (PubChem CID: 36523); Ligand affinity; Pharmacological lineage analysis; Substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)- (PubChem CID: 131091); Substance P antagonist; Substance P, Phe(5)-Trp(7,9)-Leu(11)- (PubChem CID: 25077998); Vasopressin/oxytocin receptors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia P / Receptores de Vasopresinas / Receptores de Oxitocina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos

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