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Habitual sleep-wake behaviors and lifestyle as predictors of diurnal cortisol patterns in young breast cancer survivors: a longitudinal study.
Hsiao, Fei-Hsiu; Kuo, Wen-Hung; Jow, Guey-Mei; Chang, King-Jen; Yang, Po-Sheng; Lam, Hung-Bun; Lee, Jie-Jen; Huang, Chiun-Sheng; Liu, Yu-Fen; Lai, Yu-Ming.
Afiliación
  • Hsiao FH; School of Nursing, College of Medicine, National Taiwan University, No.1, Jen-Ai Rd. Sec. 1, Taipei, Taiwan. Electronic address: hsiaofei@ntu.edu.tw.
  • Kuo WH; Department of Surgery, College of Medicine, National Taiwan University, Taiwan; Breast Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: brcancer@gmail.com.
  • Jow GM; School of Medicine, Fu-Jen Catholic University, 510 Chung-Cheng Road, Hsin-Chuang, Taipei, Taiwan. Electronic address: 039666@mail.fju.edu.tw.
  • Chang KJ; Department of Surgery, College of Medicine, National Taiwan University, Taiwan; Cheng Ching General Hospital, Taichung, Taiwan. Electronic address: Kingjen@ntu.edu.tw.
  • Yang PS; Department of Surgery, Mackay Memorial Hospital, Taipei 10401, Taiwan. Electronic address: psyangd0039@gmail.com.
  • Lam HB; Department of Surgery, Mackay Memorial Hospital, Taipei 10401, Taiwan. Electronic address: hungbun@ms1.mmh.org.tw.
  • Lee JJ; Department of Surgery, Mackay Memorial Hospital, Taipei 10401, Taiwan. Electronic address: jjlee@ms2.mmh.org.tw.
  • Huang CS; Department of Surgery, College of Medicine, National Taiwan University, Taiwan; Breast Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: huangcs@ntu.edu.tw.
  • Liu YF; Breast Cancer Caring Unit, Mackay Memorial Hospital, Taipei, Taiwan. Electronic address: sophia_7799@yahoo.com.tw.
  • Lai YM; School of Nursing, Chang-Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan. Electronic address: yulai@mail.cgu.edu.tw.
Psychoneuroendocrinology ; 53: 60-8, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25591116
OBJECTIVE: This study aimed to identify predictors of changes in diurnal cortisol patterns during the 8-month follow up period for young breast cancer survivors. Among the potential predictors were tumor size, lymph node metastasis, changes in sleep problems, habitual time of awakening and bedtime, physical activity levels, body mass index (BMI), and depressive levels across 8 months. METHODS: The participants were 62 breast cancer women who were aged 40 years and below, and had completed active breast cancer treatment. The longitudinal data were collected at four points: baseline assessment (T0) and three follow-ups after baseline: T1 (in the 2nd month), T2 (in the 5th month), and T3 (in the 8th month). The participants collected their salivary cortisol at home at six time points: upon waking, 30 and 45min after waking, and at 1200h, 1700h, and 2100h. They also completed several questionnaires: the Medical Outcomes Study Sleep scale; the Beck Depression Inventory-II, physical activity levels on a 10-point scale, time of going to bed, time of awakening, and total sleep hours. RESULTS: This study found that the main predictors of changes toward flatter diurnal cortisol patterns during the 8-month follow ups were greater tumor sizes, increases of BMI scores, and habitually later times of awakening. CONCLUSIONS: While greater tumor sizes represent biological vulnerability of disruption of cortisol circadian rhythm, maintaining an appropriate BMI and good sleep habits could be a protective factor for normal cortisol regulation, which likely helps to reduce early mortality in young breast cancer survivors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Vigilia / Neoplasias de la Mama / Hidrocortisona / Ritmo Circadiano / Sobrevivientes / Trastornos del Inicio y del Mantenimiento del Sueño / Estilo de Vida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Vigilia / Neoplasias de la Mama / Hidrocortisona / Ritmo Circadiano / Sobrevivientes / Trastornos del Inicio y del Mantenimiento del Sueño / Estilo de Vida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Psychoneuroendocrinology Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido