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Changes in body mass and metabolic profiles in patients with first-episode schizophrenia treated for 12 months with a first-generation antipsychotic.
Chiliza, B; Asmal, L; Oosthuizen, P; van Niekerk, E; Erasmus, R; Kidd, M; Malhotra, A; Emsley, R.
Afiliación
  • Chiliza B; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa. Electronic address: bonga@sun.ac.za.
  • Asmal L; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
  • Oosthuizen P; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
  • van Niekerk E; Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
  • Erasmus R; Division of Chemical Pathology, Faculty of Medicine and Health Sciences, Tygerberg, South Africa.
  • Kidd M; Centre for Statistical Consultation, Stellenbosch University, Stellenbosch, South Africa.
  • Malhotra A; Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, New York, USA.
  • Emsley R; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Eur Psychiatry ; 30(2): 277-83, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25577186
OBJECTIVES: To assess changes in body mass and metabolic profiles in patients with first-episode schizophrenia receiving standardised, assured treatment and to identify predictors and moderators of the effects. METHODS: We investigated the changes in body mass, fasting blood glucose and lipids in 107 largely antipsychotic naïve, first-episode schizophrenia patients who were treated according to a standard algorithm with long-acting injectable flupenthixol decanoate over 12 months. RESULTS: Eighty-three (78%) participants completed the 12 months of treatment, and 104 (97%) received 100% of the prescribed injections during their participation. There were significant increases in BMI (P<.0001), waist circumference (P=0.0006) and triglycerides (P=0.03) and decrease in HDL (P=0.005), while systolic (P=0.7) and diastolic blood pressure (P=0.8), LDL (P=0.1), cholesterol (P=0.3), and glucose (P=0.9) values did not change over time. The triglyceride: HDL ratio increased by 91%. Change in BMI was only correlated with change in triglycerides (P=.008). The only significant predictor of BMI increase was non-substance abuse (P=.002). CONCLUSIONS: The risks of weight gain and metabolic syndrome associated with antipsychotic treatment in first-episode schizophrenia are not restricted to second generation antipsychotics. This is a global problem, and developing communities may be particularly susceptible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Antipsicóticos / Triglicéridos / Glucemia / Índice de Masa Corporal / Colesterol / Síndrome Metabólico / Flupentixol Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Eur Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Antipsicóticos / Triglicéridos / Glucemia / Índice de Masa Corporal / Colesterol / Síndrome Metabólico / Flupentixol Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Africa Idioma: En Revista: Eur Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido