Polymorphonuclear neutrophils: an effective antimicrobial force.
Rev Infect Dis
; 11 Suppl 7: S1532-44, 1989.
Article
en En
| MEDLINE
| ID: mdl-2557663
The production and deployment of polymorphonuclear neutrophils (PMNs) are under close regulation. PMNs interact through cytokines with a number of cell types, including macrophages, lymphocytes, and endothelial cells. PMNs are guided by bacterial products and cytokines to target sites, where microbes are recognized and killed. Killing occurs through oxygen-dependent and oxygen-independent mechanisms. The frequent and severe infections seen in patients with defects (either congenital or acquired) in PMN function demonstrate the importance of PMNs in host defense against infection. PMNs are potent inflammatory cells and can exacerbate disease states such as myocardial ischemia, gram-negative bacterial sepsis, and the adult respiratory distress syndrome.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neutrófilos
Límite:
Humans
Idioma:
En
Revista:
Rev Infect Dis
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Estados Unidos