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Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.
Tan, An S; Baty, James W; Dong, Lan-Feng; Bezawork-Geleta, Ayenachew; Endaya, Berwini; Goodwin, Jacob; Bajzikova, Martina; Kovarova, Jaromira; Peterka, Martin; Yan, Bing; Pesdar, Elham Alizadeh; Sobol, Margarita; Filimonenko, Anatolyj; Stuart, Shani; Vondrusova, Magdalena; Kluckova, Katarina; Sachaphibulkij, Karishma; Rohlena, Jakub; Hozak, Pavel; Truksa, Jaroslav; Eccles, David; Haupt, Larisa M; Griffiths, Lyn R; Neuzil, Jiri; Berridge, Michael V.
Afiliación
  • Tan AS; Malaghan Institute of Medical Research, P.O. Box 7060, Wellington 6242, New Zealand.
  • Baty JW; Malaghan Institute of Medical Research, P.O. Box 7060, Wellington 6242, New Zealand.
  • Dong LF; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Bezawork-Geleta A; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Endaya B; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Goodwin J; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Bajzikova M; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Kovarova J; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Peterka M; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Yan B; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Pesdar EA; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Sobol M; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Filimonenko A; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Stuart S; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
  • Vondrusova M; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Kluckova K; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Sachaphibulkij K; School of Medical Science, Griffith University, Southport, QLD 4222, Australia.
  • Rohlena J; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Hozak P; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Truksa J; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic.
  • Eccles D; Malaghan Institute of Medical Research, P.O. Box 7060, Wellington 6242, New Zealand.
  • Haupt LM; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
  • Griffiths LR; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
  • Neuzil J; School of Medical Science, Griffith University, Southport, QLD 4222, Australia; Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic. Electronic address: j.neuzil@griffith.edu.au.
  • Berridge MV; Malaghan Institute of Medical Research, P.O. Box 7060, Wellington 6242, New Zealand. Electronic address: mberridge@malaghan.org.nz.
Cell Metab ; 21(1): 81-94, 2015 Jan 06.
Article en En | MEDLINE | ID: mdl-25565207
We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells. This leads to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth. Cell lines from circulating tumor cells showed further recovery of mitochondrial respiration and an intermediate lag to tumor growth, while cells from lung metastases exhibited full restoration of respiratory function and no lag in tumor growth. Stepwise assembly of mitochondrial respiratory (super)complexes was correlated with acquisition of respiratory function. Our findings indicate horizontal transfer of mtDNA from host cells in the tumor microenvironment to tumor cells with compromised respiratory function to re-establish respiration and tumor-initiating efficacy. These results suggest pathophysiological processes for overcoming mtDNA damage and support the notion of high plasticity of malignant cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mitocondrias Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mitocondrias Límite: Animals Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2015 Tipo del documento: Article País de afiliación: Nueva Zelanda Pais de publicación: Estados Unidos