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PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.
Wang, Kai; Zhang, Qin; Li, Danan; Ching, Keith; Zhang, Cathy; Zheng, Xianxian; Ozeck, Mark; Shi, Stephanie; Li, Xiaorong; Wang, Hui; Rejto, Paul; Christensen, James; Olson, Peter.
Afiliación
  • Wang K; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Zhang Q; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Li D; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Ching K; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Zhang C; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Zheng X; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Ozeck M; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Shi S; External Research Solutions, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Li X; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Wang H; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Rejto P; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Christensen J; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California.
  • Olson P; Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California. peter.olson@pfizer.com.
Clin Cancer Res ; 21(6): 1487-96, 2015 Mar 15.
Article en En | MEDLINE | ID: mdl-25564152
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Notch / Receptor Notch1 / Receptor Notch2 / Secretasas de la Proteína Precursora del Amiloide / Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Notch / Receptor Notch1 / Receptor Notch2 / Secretasas de la Proteína Precursora del Amiloide / Neoplasias de la Mama Triple Negativas Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos