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Fasting gut hormone levels change with modest weight loss in obese adolescents.
Jensen, D E; Nguo, K; Baxter, K A; Cardinal, J W; King, N A; Ware, R S; Truby, H; Batch, J A.
Afiliación
  • Jensen DE; Children's Health Queensland Hospital and Health Service, Department of Endocrinology and Diabetes, Royal Children's Hospital, Herston, Queensland, Australia.
  • Nguo K; Queensland Children's Medical Research Institute, University of Queensland, Herston, Queensland, Australia.
  • Baxter KA; Department of Nutrition and Dietetics, Monash University, Clayton, Victoria, Australia.
  • Cardinal JW; Children's Nutrition Research Centre, University of Queensland, Herston, Queensland, Australia.
  • King NA; Chemical Pathology, Pathology Queensland, Herston, Queensland, Australia.
  • Ware RS; Institute of Health and Biomedical Innovation, School of Exercise and Nutrition Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
  • Truby H; Queensland Children's Medical Research Institute, University of Queensland, Herston, Queensland, Australia.
  • Batch JA; School of Population Health, University of Queensland, Herston, Queensland, Australia.
Pediatr Obes ; 10(5): 380-7, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25559355
BACKGROUND: Gut hormones change with weight loss in adults but are not well studied in obese youth. OBJECTIVE: The primary aim was to evaluate how gut hormones and subjective appetite measure change with dietary weight loss in obese adolescents. METHODS: Participants were a subset of those taking part in the 'Eat Smart Study'. They were aged 10-17 years with body mass index (BMI) > 90th centile and were randomized to one of three groups: wait-listed control, structured reduced carbohydrate or structured low-fat dietary intervention for 12 weeks. Outcomes were fasting glucose, insulin, leptin, adiponectin, total amylin, acylated ghrelin, active glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide (GIP), pancreatic polypeptide (PP) and total peptide tyrosine-tyrosine. Pre- and postprandial subjective sensations of appetite were assessed using visual analogue scales. RESULTS: Of 87 'Eat Smart' participants, 74 participated in this sub-study. The mean (standard deviation) BMI z-score was 2.1 (0.4) in the intervention groups at week 12 compared with 2.2 (0.4) in the control group. Fasting insulin (P = 0.05) and leptin (P = 0.03) levels decreased, while adiponectin levels increased (P = 0.05) in the intervention groups compared with control. The intervention groups were not significantly different from each other. A decrease in BMI z-score at week 12 was associated with decreased fasting insulin (P < 0.001), homeostatic model of assessment-insulin resistance (P < 0.001), leptin (P < 0.001), total amylin (P = 0.03), GIP (P = 0.01), PP (P = 0.02) and increased adiponectin (P < 0.001). There was no significant difference in appetite sensations. CONCLUSIONS: Modest weight loss in obese adolescents leads to changes in some adipokines and gut hormones that may favour weight regain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipéptido Inhibidor Gástrico / Ghrelina / Obesidad Infantil Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Pediatr Obes Año: 2015 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polipéptido Inhibidor Gástrico / Ghrelina / Obesidad Infantil Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Pediatr Obes Año: 2015 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido