In vivo analysis of biodegradable liposome gold nanoparticles as efficient agents for photothermal therapy of cancer.
Nano Lett
; 15(2): 842-8, 2015 Feb 11.
Article
en En
| MEDLINE
| ID: mdl-25554860
We report biodegradable plasmon resonant liposome gold nanoparticles (LiposAu NPs) capable of killing cancer cells through photothermal therapy. The pharmacokinetic study of LiposAu NPs performed in a small animal model indicates in situ degradation in hepatocytes and further getting cleared through the hepato-biliary and renal route. Further, the therapeutic potential of LiposAu NPs tested in mouse tumor xenograft model using NIR laser (750 nm) illumination resulted in complete ablation of the tumor mass, thus prolonging disease-free survival.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fototerapia
/
Materiales Biocompatibles
/
Nanopartículas del Metal
/
Oro
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Hipertermia Inducida
/
Liposomas
/
Neoplasias
Límite:
Animals
Idioma:
En
Revista:
Nano Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos