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Parainfluenza virus 5 expressing the G protein of rabies virus protects mice after rabies virus infection.
Huang, Ying; Chen, Zhenhai; Huang, Junhua; Fu, ZhenFang; He, Biao.
Afiliación
  • Huang Y; Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
  • Chen Z; Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
  • Huang J; Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.
  • Fu Z; Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA zhenfu@uga.edu bhe@uga.edu.
  • He B; Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA zhenfu@uga.edu bhe@uga.edu.
J Virol ; 89(6): 3427-9, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25552723
Rabies remains a major public health threat around the world. Once symptoms appear, there is no effective treatment to prevent death. In this work, we tested a recombinant parainfluenza virus 5 (PIV5) strain expressing the glycoprotein (G) of rabies (PIV5-G) as a therapy for rabies virus infection: we have found that PIV5-G protected mice as late as 6 days after rabies virus infection. PIV5-G is a promising vaccine for prevention and treatment of rabies virus infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabia / Virus de la Rabia / Vacunas Antirrábicas / Proteínas del Envoltorio Viral / Virus de la Parainfluenza 5 / Vectores Genéticos Límite: Animals / Humans Idioma: En Revista: J Virol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabia / Virus de la Rabia / Vacunas Antirrábicas / Proteínas del Envoltorio Viral / Virus de la Parainfluenza 5 / Vectores Genéticos Límite: Animals / Humans Idioma: En Revista: J Virol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos