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Relationship between serum IgA/C3 ratio and severity of histological lesions using the Oxford classification in children with IgA nephropathy.
Mizerska-Wasiak, Malgorzata; Maldyk, Jadwiga; Rybi-Szuminska, Agnieszka; Wasilewska, Anna; Miklaszewska, Monika; Pietrzyk, Jacek; Firszt-Adamczyk, Agnieszka; Stankiewicz, Roman; Bienias, Beata; Zajaczkowska, Malgorzata; Gadomska-Prokop, Katarzyna; Grenda, Ryszard; Pukajlo-Marczyk, Agnieszka; Zwolinska, Danuta; Szczepanska, Maria; Turczyn, Agnieszka; Roszkowska-Blaim, Maria.
Afiliación
  • Mizerska-Wasiak M; Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland, wasiaczki@wp.pl.
Pediatr Nephrol ; 30(7): 1113-20, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25549975
BACKGROUND: The aim of this study was to evaluate the usefulness of serum immunoglobulin A/complement factor 3 (IgA/C3) ratio for predicting histological severity of kidney lesions in children with IgA nephropathy (IgAN) based on World Health Organization (WHO) and the Oxford classification (OC). METHODS: We studied 89 children with IgAN with a mean age of 11.38 ± 4.1 years (range 2-18 years). Based on available medical records, we retrospectively evaluated clinical data, IgA/C3 ratio, and kidney biopsy findings using the five-grade WHO classification and the OC The mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S), tubular atrophy/interstitial fibrosis (T) (MEST) score (absent = 0, present = 1) calculated as the sum of M+E+S+T ranging from 0 to 4. RESULTS: Mean IgA/C3 ratio values were significantly higher (P < 0.05) in patients with M1, S1, and T1 compared with M0, S0, and T0, respectively (P < 0.05); there were no differences in the WHO classification. We found a significant positive correlation between the IgA/C3 ratio and proteinuria (r = 0.24) and determined optimal cutoff values of the IgA/C3 ratio, with a corresponding confidence interval for specific MEST scores. CONCLUSIONS: The IgA/C3 ratio in children with IgAN may be a useful marker of the severity of lesions found in kidney biopsy as evaluated using the OC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C3 / Inmunoglobulina A / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C3 / Inmunoglobulina A / Glomerulonefritis por IGA Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2015 Tipo del documento: Article Pais de publicación: Alemania