Absence of Annexin A1 impairs host adaptive immunity against Mycobacterium tuberculosis in vivo.
Immunobiology
; 220(5): 614-23, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25533809
The role of Annexin A1 (ANXA1) in counter-regulating the activities of innate immune cells, such as the migration of neutrophils and monocytes, and the generation of pro-inflammatory mediators in various models of inflammatory and autoimmune diseases is well documented. However, while ANXA1 has been proposed as an important mediator of the adaptive immune response, its involvement in this respect has been less studied. Furthermore, while there have been numerous studies on the role of ANXA1 in inflammatory diseases, less has been reported on its influence in immunity against infection. A recent study reported a link between ANXA1 and tuberculosis, and proposed a model in which Mycobacterium tuberculosis exerts its virulence by manipulating the ANXA1-mediated host apoptotic response. This has prompted us to further investigate the role of ANXA1 in the pathogenesis of tuberculosis in vivo. Here, we show that ANXA1(-/-) mice are more susceptible to M. tuberculosis infection, as evidenced by a transient increase in the pulmonary bacterial burden, and exacerbated and disorganized granulomatous inflammation. These pathological manifestations correlated with an impaired ability of ANXA1(-/-) dendritic cells to activate naïve T cells, thereby supporting a role for ANXA1 in shaping the adaptive immunity against M. tuberculosis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
/
Células Dendríticas
/
Linfocitos T
/
Anexina A1
/
Granuloma
/
Pulmón
/
Mycobacterium tuberculosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunobiology
Año:
2015
Tipo del documento:
Article
País de afiliación:
Singapur
Pais de publicación:
Países Bajos