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Quantitative structure-activity relationships for chronic toxicity of alkyl-chrysenes and alkyl-benz[a]anthracenes to Japanese medaka embryos (Oryzias latipes).
Lin, Hongkang; Morandi, Garrett D; Brown, R Stephen; Snieckus, Victor; Rantanen, Toni; Jørgensen, Kåre B; Hodson, Peter V.
Afiliación
  • Lin H; Department of Biology, Queen's University, Kingston, Ontario K7L3N6, Canada.
  • Morandi GD; School of Environmental Studies, Queen's University, Kingston, Ontario K7L3N6, Canada.
  • Brown RS; School of Environmental Studies, Queen's University, Kingston, Ontario K7L3N6, Canada; Department of Chemistry, Queen's University, Kingston, Ontario K7L3N6, Canada.
  • Snieckus V; Department of Chemistry, Queen's University, Kingston, Ontario K7L3N6, Canada.
  • Rantanen T; Department of Chemistry, Queen's University, Kingston, Ontario K7L3N6, Canada.
  • Jørgensen KB; Department of Mathematics and Natural Sciences, University of Stavanger, 4036 Stavanger, Norway.
  • Hodson PV; Department of Biology, Queen's University, Kingston, Ontario K7L3N6, Canada; School of Environmental Studies, Queen's University, Kingston, Ontario K7L3N6, Canada. Electronic address: peter.hodson@queensu.ca.
Aquat Toxicol ; 159: 109-18, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25528422
Alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs) are a class of compounds found at significant concentrations in crude oils, and likely the main constituents responsible for the chronic toxicity of oil to fish. Alkyl substituents at different locations on the aromatic rings change the size and shape of PAH molecules, which results in different interactions with tissue receptors and different severities of toxicity. The present study is the first to report the toxicity of several alkylated derivatives of chrysene and benz[a]anthracene to the embryos of Japanese medaka (Oryzias latipes) using the partition controlled delivery (PCD) method of exposure. The PCD method maintained the desired exposure concentrations by equilibrium partitioning of hydrophobic test compounds from polydimethylsiloxane (PDMS) films. Test concentrations declined by only 13% over a period of 17 days. Based on the prevalence of signs of blue sac disease (BSD), as expressed by median effective concentrations (EC50s), benz[a]anthracene (B[a]A) was more toxic than chrysene. Alkylation generally increased toxicity, except at position 2 of B[a]A. Alkyl-PAHs substituted in the middle region had a lower EC50 than those substituted at the distal region. Except for B[a]A and 7-methylbenz[a]anthracene (7-MB), estimated EC50 values were higher than their solubility limits, which resulted in limited toxicity within the range of test concentrations. The regression between log EC50s and logKow values provided a rough estimation of structure-activity relationships for alkyl-PAHs, but Kow alone did not provide a complete explanation of the chronic toxicity of alkyl PAHs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oryzias / Crisenos / Antracenos Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oryzias / Crisenos / Antracenos Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Países Bajos