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Solubilization and stabilization of macular carotenoids by water soluble oligosaccharides and polysaccharides.
Apanasenko, Irina E; Selyutina, Olga Yu; Polyakov, Nikolay E; Suntsova, Lyubov P; Meteleva, Elizaveta S; Dushkin, Alexander V; Vachali, Preejith; Bernstein, Paul S.
Afiliación
  • Apanasenko IE; Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
  • Selyutina OY; Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
  • Polyakov NE; Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia. Electronic address: polyakov@kinetics.nsc.ru.
  • Suntsova LP; Institute of Solid State Chemistry and Mechanochemistry, Novosibirsk, Russia.
  • Meteleva ES; Institute of Solid State Chemistry and Mechanochemistry, Novosibirsk, Russia.
  • Dushkin AV; Institute of Solid State Chemistry and Mechanochemistry, Novosibirsk, Russia.
  • Vachali P; Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Bernstein PS; Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT, USA.
Arch Biochem Biophys ; 572: 58-65, 2015 Apr 15.
Article en En | MEDLINE | ID: mdl-25527162
Xanthophyll carotenoids zeaxanthin and lutein play a special role in the prevention and treatment of visual diseases. These carotenoids are not produced by the human body and must be consumed in the diet. On the other hand, extremely low water solubility of these carotenoids and their instability restrict their practical application as components of food or medicinal formulations. Preparation of supramolecular complexes of zeaxanthin and lutein with glycyrrhizic acid, its disodium salt and the natural polysaccharide arabinogalactan allows one to minimize the aforementioned disadvantages when carotenoids are used in food processing as well as for production of therapeutic formulations with enhanced solubility and stability. In the present study, the formation of supramolecular complexes was investigated by NMR relaxation, surface plasmon resonance (SPR) and optical absorption techniques. The complexes increase carotenoid solubility more than 1000-fold. The kinetics of carotenoid decay in reactions with ozone molecules, hydroperoxyl radicals and metal ions were measured in water and organic solutions, and significant increases in oxidation stability of lutein and zeaxanthin in arabinogalactan and glycyrrhizin complexes were detected.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Luteína / Agua / Zeaxantinas / Galactanos / Mácula Lútea Idioma: En Revista: Arch Biochem Biophys Año: 2015 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligosacáridos / Luteína / Agua / Zeaxantinas / Galactanos / Mácula Lútea Idioma: En Revista: Arch Biochem Biophys Año: 2015 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos