Your browser doesn't support javascript.
loading
Effectiveness of bacterial infection-related cytokine profile (BIRCP) determination for monitoring pathogen infections in children with hemopathy in the bone marrow inhibition phase.
Chen, X D; Chen, B; Tang, Y M; Song, H; Shi, S W; Yang, S L; Xu, W Q; Pan, B H; Zhao, F Y; Zhao, N; Zhang, L Y; Mao, J Q.
Afiliación
  • Chen XD; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China xddoccn@yeah.net.
  • Chen B; Department of Rehabilitation, Hangzhou Hospital of the Zhejiang Armed Police Corps, Hangzhou, Zhejiang Province, China.
  • Tang YM; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Song H; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Shi SW; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Yang SL; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Xu WQ; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Pan BH; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Zhao FY; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Zhao N; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Zhang LY; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
  • Mao JQ; Department of Hematology and Oncology, Children's Hospital Affiliated with Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Genet Mol Res ; 13(4): 10622-31, 2014 Dec 18.
Article en En | MEDLINE | ID: mdl-25526183
Serum cytokine profiles were analyzed before and after infection in children with hemopathy in the bone marrow inhibition phase to explore the utility of cytokine variations for detecting infections. Serum Th1/Th2 cytokine levels, including tumor necrosis factor, interleukin (IL)-2, IL-4, IL-6, IL-10, and interferon, were quantitatively determined by cytometric bead array technology in 480 cases (230 children) of children with hemopathy in the bone marrow inhibition phase with signs of infection, such as fever, and without, to establish baseline and affected levels for comparison with healthy control children. We used the cytokine profile of infected, blood culture-positive children to establish a bacterial infection-related cytokine profile (BIRCP) for predicting infections by pathogens in blood culture-negative children. Overall, 82.9% of children with Gram-negative bacterial infections were accompanied by marked increases of IL-6 and IL-10 levels [>10 times (means ± SD)], whereas only a mild increase of IL-6 levels occurred in Gram-positive bacteria-infected children [>2 times (means ± SD)] and only a mild increase of IFN-γ levels occurred in fungal culture-positive children [>2 times (means ± SD)]. Gram-positive bacterial and fungal infections did not cause a marked increase in IL-6 or IL- 10 levels. The effective rate (86.05%, N = 43) of infectious cases predicted by BIRCP was significantly higher than that obtained using traditional methods for selecting antibiotics based on clinical indications (65.45%, N = 55, P < 0.05). In summary, BIRCP can be used to predict the infections by pathogens in children with hemopathy and to select appropriate antibiotics.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Médula Ósea / Interleucinas / Interferón gamma / Factor de Necrosis Tumoral alfa / Transcriptoma / Bacterias Grampositivas / Enfermedades Hematológicas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Genet Mol Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Médula Ósea / Interleucinas / Interferón gamma / Factor de Necrosis Tumoral alfa / Transcriptoma / Bacterias Grampositivas / Enfermedades Hematológicas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Genet Mol Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil