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Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice.
Goes, Annya Costa Araujo de Macedo; Pinto, Francisco Maxwell Martins; Fernandes, Guilherme Cardoso; Barbosa, Jessica Sales; Correia, Emanuela Santos; Ribeiro, Ronaldo Albuquerque; Guimaraes, Sergio Botelho; Lima Júnior, Roberto Cesar Pereira; Brito, Gerly Anne de Castro; Rodrigues, Lusmar Veras.
Afiliación
  • Goes AC; Department of Surgery, Federal University of Ceara, Fortaleza, CE, Brazil.
  • Pinto FM; School of Pharmacy, UFC, Fortaleza, CE, Brazil.
  • Fernandes GC; School of Pharmacy, UFC, Fortaleza, CE, Brazil.
  • Barbosa JS; School of Medicine, UFC, Fortaleza, CE, Brazil.
  • Correia ES; Walter Cantidio Hospital, UFC, Fortaleza, CE, Brazil.
  • Ribeiro RA; Department of Surgery, UFC, Fortaleza, CE, Brazil.
  • Guimaraes SB; UFC, Fortaleza, CE, Brazil.
  • Lima Júnior RC; Department of Pharmacology, UFC, Fortaleza, CE, Brazil.
  • Brito GA; Department of Morphology, UFC, Fortaleza, CE, Brazil.
  • Rodrigues LV; Department of Surgery, UFC, Fortaleza, CE, Brazil.
Acta Cir Bras ; 29(12): 787-93, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25517491
PURPOSE: To study the anti-inflammatory actions of electroacupuncture (EAc) on an experimental colitis model in mice. METHODS: Thirty-eight male Swiss mice, divided in five groups, were subjected to induction of colitis by TNBS in 50% ethanol. Saline (SAL) and ethanol (ETNL) groups served as controls. TNBS+EAc and TNBS+ dexamethasone subgroups were treated with EAc 100Hz and dexamethasone (DEXA) 1 mg/Kg/day, respectively. After three days, a colon segment was obtained for quantification of myeloperoxidase (MPO) activity, immunohistochemistry for iNOS, malondialdehyde (MDA) and cytokines (IL-1ß and IL-10). RESULTS: Neutrophilic activity, assayed as MPO activity, was significantly higher in the TNBS colitis group than that in the saline control group. TNBS+EAc group showed suppression of IL-10 in the colon. EAc treatment significantly reduced the concentration of MDA and the expression of iNOS, as compared to the other groups. CONCLUSION: Electroacupuncture 100Hz applied to acupoint ST-36 promotes an anti-inflammatory action on the TNBS-induced colitis, mediated by increase of IL-10 and decrease of iNOS expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Interleucina-10 / Colitis / Peroxidasa / Óxido Nítrico Sintasa de Tipo II / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Interleucina-10 / Colitis / Peroxidasa / Óxido Nítrico Sintasa de Tipo II / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Acta Cir Bras Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil