[Influence of omega-3 polyunsaturated fatty acids on oxidative stress and cytochrome P450 2E1 expression in rat liver].
Ukr Biochem J
; 86(4): 132-7, 2014.
Article
en Uk
| MEDLINE
| ID: mdl-25509192
Polyunsaturated fatty acids (PUFAs), omega-3 ones in particular, form phospholipid layer of biological membranes, which provides normal functioning of membrane-associated complexes of enzymes and transmembrane transport. Free omega-3 PUFAs regulate the transcription of many genes, and thereby have an effect on the level of metabolic processes, particularly control of lipid and carbohydrate metabolism in the liver. Cytochrome P450 2El (1.14.14.1) causes the transformation of lipophilic exogenous and endogenous substances, as well as involvement in homeostasis, both at the cellular and systemic levels. The aim is to study changes in expression of cytochrome P450 2E1, and to assess the antioxidant system and the level of peroxidation processes in the liver of experimental animals under the chronic action omega-3 PUFAs. During experiment more than two-fold increase in the content of cytochrome P450 2El was observed in the liver of rats which additionally received omega-3 PUFAs for 4 weeks in the standard daily diet. At the same time, such changes in the enzyme expression did not lead to an imbalance of pro- and antioxidant processes in the liver.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Omega-3
/
Estrés Oxidativo
/
Citocromo P-450 CYP2E1
/
Inductores del Citocromo P-450 CYP2E1
/
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Límite:
Animals
Idioma:
Uk
Revista:
Ukr Biochem J
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Ucrania