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Everolimus associated with low-dose calcineurin inhibitors, an option in kidney transplant recipients of very old donors.
Furian, L; Silvestre, C; Vallese, L; Baldan, N; Donato, P; Bonfante, L; Cavallin, F; Marchini, F; Rigotti, P.
Afiliación
  • Furian L; Kidney and Pancreas Transplantation Unit, Padua, Italy. Electronic address: lucrezia.furian@unipd.it.
  • Silvestre C; Kidney and Pancreas Transplantation Unit, Padua, Italy.
  • Vallese L; Kidney and Pancreas Transplantation Unit, Padua, Italy.
  • Baldan N; Kidney and Pancreas Transplantation Unit, Padua, Italy.
  • Donato P; Kidney and Pancreas Transplantation Unit, Padua, Italy.
  • Bonfante L; Nephrology Unit, Padua, Italy.
  • Cavallin F; Veneto Institute of Oncology (IOV-IRCCS), Padua, Italy.
  • Marchini F; Nephrology Unit, Padua, Italy.
  • Rigotti P; Kidney and Pancreas Transplantation Unit, Padua, Italy.
Transplant Proc ; 46(10): 3390-5, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25498057
BACKGROUND: Despite potential renal and cardiovascular advantages of proliferation signal inhibitors, their de novo use in kidney transplantation (KT) from elderly donors (ED) is poorly documented. We retrospectively analyzed two consecutive cohorts of KT from ED: low-dose extended-release tacrolimus (Tac) was used from 2010 to 2012 and cyclosporine (Csa) was used from 2008 to 2010. METHODS: Associated maintenance drugs were everolimus (Eve) and steroids. Outcomes were compared between groups over a 12-month follow-up. Fifty-six patients were analyzed in the Tac-Eve group and 54 in the Csa-Eve group. RESULTS: There were no significant differences at baseline with the exception of older donors age in the Tac-Eve cohort (74 vs 71 years, P = .002). There were no deaths, primary non functions, or graft losses. Eight (14%) Tac-Eve and 15 (28%) Csa-Eve patients had delayed graft function (P = .10). Renal function was fairly stable over time (median cGFR 36-49 mL/min and 51-55 mL/min in single kidney transplantation and dual kidney transplantation patients, respectively) with no significant differences between groups at month 12. Surgical complications were infrequent and observed mostly in dual kidney transplantation recipients. Thirty-nine (70%) and 30 (56%) patients remained under their initial Tac-Eve or Csa-Eve regimen, respectively. CONCLUSIONS: Induction with Thymoglobuline and maintenance with Eve and low-dose extended-release Tac and steroids is safe and effective in renal transplant from ED.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Tacrolimus / Sirolimus / Inhibidores de la Calcineurina / Inmunosupresores Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Tacrolimus / Sirolimus / Inhibidores de la Calcineurina / Inmunosupresores Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos