Effects provoked by chronic undernourishment on the fibre type composition and contractility of fast muscles in male and female developing rats.
J Anim Physiol Anim Nutr (Berl)
; 99(5): 974-86, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25495590
In this study, we compare the effects of pre- and post-natal food deprivation on the relative proportion of fibre types and contractile responses in the extensor digitorum longus (EDL) muscle of female and male rats at different post-natal ages. EDL muscles from undernourished male (UM) rats showed a higher proportion of Type IIB than IIA fibres and larger normalized twitch responses (with respect to muscle weight) than those of controls (CM). In contrast, EDL muscles from control (CF) and undernourished female rats (UF) showed no significant differences in their fibre type composition and normalized twitch forces at most of the ages analysed. Our data are indicative that the EDL muscles from undernourished males are more susceptible to the effects exerted by low food income than the EDL muscles from female rats. It is proposed that changes in the reactive oxygen species (ROS) concentration and hormonal factors, due to undernutrition, are involved in the alterations observed in the fibre type composition and force production of EDL muscles in undernourished male rats and that estrogens may have an antioxidant protective role on the undernourished EDL muscles in female rats.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras Musculares de Contracción Rápida
/
Desnutrición
Aspecto:
Determinantes_sociais_saude
Límite:
Animals
Idioma:
En
Revista:
J Anim Physiol Anim Nutr (Berl)
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
MEDICINA VETERINARIA
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Alemania