Formulation and stability of cytokine therapeutics.
J Pharm Sci
; 104(2): 307-26, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25492409
Cytokines are messenger proteins that regulate the proliferation and differentiation of cells and control immune responses. Interferons, interleukins, and growth factors have applications in cancer, autoimmune, and viral disease treatment. The cytokines are susceptible to chemical and physical instability. This article reviews the structure and stability issues of clinically used cytokines, as well as formulation strategies for improved stability. Some general aspects for identifying most probable stability concerns, selecting excipients, and developing stable cytokine formulations are presented. The vast group of cytokines offers possibilities for new biopharmaceuticals. The formulation approaches of the current cytokine products could facilitate development of new biopharmaceuticals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terapia Biológica
/
Citocinas
/
Estabilidad de Medicamentos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Pharm Sci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Estados Unidos