Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells.
Cancer Biol Ther
; 16(2): 233-43, 2015.
Article
en En
| MEDLINE
| ID: mdl-25482928
Palabras clave
Aurora kinases; BSA, bovine serum albumin; DMSO, dimethyl sulfoxide; EGFR, epidermal growth factor receptor; FITC, fluorescein isothiocyanate; Glioma; MTS, 3-[4, 5-dimethylthiazol- 2yl]-5-[3-carboxymethoxyphenyl]-2-[4-sulfophenyl]-2H, tetrazolium; NF-кB, nuclear factor кB; PAGE, polyacrylamide gel electrophoresis; PBS, phosphate-buffered saline; PDGFR, platelet derived growth factor receptor; PI, propidium iodide; PI3K, Phosphatidylinositol 3-Kinase; TBS, Tris-buffered saline; TRAIL, tumor necrosis factorrelated apoptosis inducing ligand; caspase-independent cell death; cell cycle arrest
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfonamidas
/
Triterpenos
/
Compuestos de Bifenilo
/
Ciclo Celular
/
Caspasas
/
Proteínas Inhibidoras de la Apoptosis
/
Aurora Quinasa A
/
Aurora Quinasa B
/
Glioma
/
Nitrofenoles
Límite:
Humans
Idioma:
En
Revista:
Cancer Biol Ther
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2015
Tipo del documento:
Article
Pais de publicación:
Estados Unidos