Anti-leptospiral activities of an endemic plant Glyptopetalum calocarpum (Kurz.) Prain used as a medicinal plant by Nicobarese of Andaman and Nicobar Islands.
Nat Prod Res
; 29(16): 1575-7, 2015.
Article
en En
| MEDLINE
| ID: mdl-25482276
Leaves of an endemic plant Glyptopetalum calocarpum are used by Nicobarese tribes of Andaman and Nicobar Islands, India, to prepare traditional medicine for treating fever. In the present investigation, pharmacologically active compounds were isolated from this plant and their antimicrobial efficacy was evaluated against the leptospiral strains. The anti-leptospiral activity of six plant-derived compounds was determined by both microdilution and macrodilution methods. Two out of six compounds, namely lupenone and stigmasterol, showed anti-leptospiral activity. The minimum inhibitory concentrations of the two compounds tested against pathogenic leptospiral strains belonging to 10 serovars were in the range of 100-200 µg/mL. The range of minimum bactericidal concentrations was 400-800 µg/mL. Compounds lupenone, stigmasterol, lupeol, ß-amyrin and ß-amyrin acetate had negligible or no haemolytic activity, exhibiting IC50 values of greater than 5 mg/mL. Further in vivo studies are needed to investigate the pharmacological and toxicological properties of G. calocarpum before it can be considered as a new anti-leptospiral agent.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plantas Medicinales
/
Estigmasterol
/
Triterpenos
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Celastraceae
/
Leptospira
/
Antibacterianos
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Año:
2015
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Reino Unido