Your browser doesn't support javascript.
loading
Dimethyl sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells.
Lin, Gu-Jiun; Sytwu, Huey-Kang; Yu, Jyh-Cherng; Chen, Yuan-Wu; Kuo, Yu-Liang; Yu, Chiao-Chi; Chang, Hao-Ming; Chan, De-Chuan; Huang, Shing-Hwa.
Afiliación
  • Lin GJ; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Sytwu HK; Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Yu JC; Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Chen YW; School of Dentistry, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Kuo YL; Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ROC; School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ROC.
  • Yu CC; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, ROC; Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Chang HM; Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Chan DC; Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
  • Huang SH; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, ROC; Department of General Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address: h610129@gmail.com.
Toxicol Appl Pharmacol ; 282(2): 207-14, 2015 Jan 15.
Article en En | MEDLINE | ID: mdl-25481496
Type 1 diabetes mellitus (T1D) is caused by the destruction of insulin-producing ß cells in pancreatic islets by autoimmune T cells. Islet transplantation has been established as an effective therapeutic strategy for T1D. However, the survival of islet grafts can be disrupted by recurrent autoimmunity. Dimethyl sulfoxide (DMSO) is a solvent for organic and inorganic substances and an organ-conserving agent used in solid organ transplantations. DMSO also exerts anti-inflammatory, reactive oxygen species scavenger and immunomodulatory effects and therefore exhibits therapeutic potential for the treatment of several human inflammatory diseases. In this study, we investigated the therapeutic potential of DMSO in the inhibition of autoimmunity. We treated an animal model of islet transplantation (NOD mice) with DMSO. The survival of the syngeneic islet grafts was significantly prolonged. The population numbers of CD8, DC and Th1 cells were decreased, and regulatory T (Treg) cell numbers were increased in recipients. The expression levels of IFN-γ and proliferation of T cells were also reduced following DMSO treatment. Furthermore, the differentiation of Treg cells from naive CD4 T cells was significantly increased in the in vitro study. Our results demonstrate for the first time that in vivo DMSO treatment suppresses spontaneous diabetes and autoimmune recurrence in NOD mice by inhibiting the Th1 immune response and inducing the differentiation of Treg cells.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Dimetilsulfóxido / Linfocitos T Reguladores / Diabetes Mellitus Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Dimetilsulfóxido / Linfocitos T Reguladores / Diabetes Mellitus Límite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos