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Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.
Bruedigam, Claudia; Bagger, Frederik O; Heidel, Florian H; Paine Kuhn, Catherine; Guignes, Solene; Song, Axia; Austin, Rebecca; Vu, Therese; Lee, Erwin; Riyat, Sarbjit; Moore, Andrew S; Lock, Richard B; Bullinger, Lars; Hill, Geoffrey R; Armstrong, Scott A; Williams, David A; Lane, Steven W.
Afiliación
  • Bruedigam C; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Bagger FO; The Finsen Laboratory, Bioinformatics Centre, Department of Biology, and Biotech Research and Innovation Center (BRIC), University of Copenhagen, 1165 Copenhagen, Denmark.
  • Heidel FH; Department of Hematology and Oncology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany.
  • Paine Kuhn C; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Guignes S; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Song A; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Austin R; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Vu T; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Lee E; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
  • Riyat S; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia.
  • Moore AS; Queensland Children's Medical Research Institute, Brisbane, QLD 4029, Australia; University of Queensland, Brisbane, QLD 4072, Australia.
  • Lock RB; Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
  • Bullinger L; Department of Hematology and Oncology, University Hospital Ulm, 89081 Ulm, Germany.
  • Hill GR; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia.
  • Armstrong SA; Department of Pediatrics, Memorial Sloan Kettering Leukemia Center, New York, NY 10065, USA.
  • Williams DA; Division of Hematology and Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  • Lane SW; Division of Immunology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology, Royal Brisbane and Women's Hospital, Brisbane, QLD 4006, Australia; University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: steven.lane@qimrberghofer.edu.
Cell Stem Cell ; 15(6): 775-90, 2014 Dec 04.
Article en En | MEDLINE | ID: mdl-25479751
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Leucemia Mieloide Aguda / Proteína p53 Supresora de Tumor / Niacinamida / Telomerasa / Indoles Límite: Animals / Humans Idioma: En Revista: Cell Stem Cell Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Leucemia Mieloide Aguda / Proteína p53 Supresora de Tumor / Niacinamida / Telomerasa / Indoles Límite: Animals / Humans Idioma: En Revista: Cell Stem Cell Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos