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Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance.
Xiao, Meng; Fan, Xin; Chen, Sharon C-A; Wang, He; Sun, Zi-Yong; Liao, Kang; Chen, Shu-Lan; Yan, Yan; Kang, Mei; Hu, Zhi-Dong; Chu, Yun-Zhuo; Hu, Tie-Shi; Ni, Yu-Xing; Zou, Gui-Ling; Kong, Fanrong; Xu, Ying-Chun.
Afiliación
  • Xiao M; Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China.
  • Fan X; Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
  • Chen SC; Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR - Pathology West, Westmead Hospital, University of Sydney, New South Wales, Australia.
  • Wang H; Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
  • Sun ZY; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liao K; Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Chen SL; Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yan Y; Department of Clinical Laboratory, Peking University First Hospital, Beijing, China.
  • Kang M; Laboratory of Clinical Microbiology, West China Hospital, Sichuan University, Chengdu, China.
  • Hu ZD; Department of Clinical Laboratory, Tianjin Medical University General Hospital, Tianjin, China.
  • Chu YZ; Department of Clinical Laboratory, The First Hospital of China Medical University, Shenyang, China.
  • Hu TS; Department of Clinical Laboratory, The People's Hospital of Liaoning Province, Shenyang, China.
  • Ni YX; Department of Clinical Microbiology and Infection Control, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai, China.
  • Zou GL; Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Kong F; Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR - Pathology West, Westmead Hospital, University of Sydney, New South Wales, Australia.
  • Xu YC; Department of Clinical Laboratory, Peking Union Medical College Hospital, Beijing, China xycpumch@139.com.
J Antimicrob Chemother ; 70(3): 802-10, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25473027
OBJECTIVES: To define the antifungal susceptibility patterns of the most common non-albicans Candida spp. in China. METHODS: We evaluated the susceptibilities to nine antifungal drugs of Candida parapsilosis species complex, Candida tropicalis, Candida glabrata species complex and Candida krusei isolates from patients with invasive candidiasis at 11 hospitals over 3 years. Isolates were identified by MALDI-TOF MS supplemented by DNA sequencing. MICs were determined by Sensititre YeastOne(TM) using current clinical breakpoints/epidemiological cut-off values to assign susceptibility (or WT), and by CLSI M44-A2 disc diffusion for fluconazole and voriconazole. RESULTS: Of 1072 isolates, 392 (36.6%) were C. parapsilosis species complex. C. tropicalis, C. glabrata species complex and C. krusei comprised 35.4%, 24.3% and 3.7% of the isolates, respectively. Over 99.3% of the isolates were of WT phenotype to amphotericin B and 5-flucytosine. Susceptibility/WT rates to azoles among C. parapsilosis species complex were ≥97.5%. However, 11.6% and 9.5% of C. tropicalis isolates were non-susceptible to fluconazole and voriconazole, respectively (7.1% were resistant to both). Approximately 14.3% of C. glabrata sensu stricto isolates (n = 258) were fluconazole resistant, and 11.6% of C. glabrata sensu stricto isolates were cross-resistant to fluconazole and voriconazole. All C. krusei isolates were susceptible/WT to voriconazole, posaconazole and itraconazole. Overall, 97.7%-100% of isolates were susceptible to caspofungin, micafungin and anidulafungin, but 2.3% of C. glabrata were non-susceptible to anidulafungin. There was no azole/echinocandin co-resistance. Disc diffusion and Sensititre YeastOne(TM) methods showed >95% categorical agreement for fluconazole and voriconazole. CONCLUSIONS: In summary, reduced azole susceptibility was seen among C. tropicalis. Resistance to echinocandins was uncommon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Candidiasis Invasiva / Antifúngicos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Candidiasis Invasiva / Antifúngicos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido