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Cost-effectiveness model for hepatitis C screening and treatment: Implications for Egypt and other countries with high prevalence.
Kim, David D; Hutton, David W; Raouf, Ahmed A; Salama, Mohsen; Hablas, Ahmed; Seifeldin, Ibrahim A; Soliman, Amr S.
Afiliación
  • Kim DD; a Department of Health Services , University of Washington , Seattle , WA , USA.
Glob Public Health ; 10(3): 296-317, 2015.
Article en En | MEDLINE | ID: mdl-25469976
Hepatitis C virus (HCV) infection is a major cause of cirrhosis and liver cancer, and many developing countries report intermediate-to-high prevalence. However, the economic impact of screening and treatment for HCV in high prevalence countries has not been well studied. Thus, we examined the cost-effectiveness of screening and treatment for HCV infection for asymptomatic, average-risk adults using a Markov decision analytic model. In our model, we collected age-specific prevalence, disease progression rates for Egyptians and local cost estimates in Egypt, which has the highest prevalence of HCV infection (~15%) in the world. We estimated the incremental cost-effectiveness ratio and conducted sensitivity analyses to determine how cost-effective HCV screening and treatment might be in other developing countries with high and intermediate prevalence. In Egypt, implementing a screening programme using triple-therapy treatment (sofosbuvir with pegylated interferon and ribavirin) was dominant compared with no screening because it would have lower total costs and improve health outcomes. HCV screening and treatment would also be cost-effective in global settings with intermediate costs of drug treatment (~$8000) and a higher sustained viral response rate (70-80%).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Tamizaje Masivo / Hepatitis C / Modelos Económicos Tipo de estudio: Diagnostic_studies / Health_economic_evaluation / Incidence_studies / Prevalence_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Glob Public Health Asunto de la revista: SAUDE PUBLICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Tamizaje Masivo / Hepatitis C / Modelos Económicos Tipo de estudio: Diagnostic_studies / Health_economic_evaluation / Incidence_studies / Prevalence_studies / Prognostic_studies / Screening_studies Aspecto: Patient_preference Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Glob Public Health Asunto de la revista: SAUDE PUBLICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido