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Taenia solium infection in Peru: a collaboration between Peace Corps Volunteers and researchers in a community based study.
Watts, Nathaniel S; Pajuelo, Monica; Clark, Taryn; Loader, Maria-Cristina I; Verastegui, Manuela R; Sterling, Charles; Friedland, Jon S; Garcia, Hector H; Gilman, Robert H.
Afiliación
  • Watts NS; Department of Epidemiology, Boston University School of Public Health, Boston, United States of America.
  • Pajuelo M; Unit of Bioinformatics and Molecular Biology, School of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Clark T; Weill Cornell Medical College, New York, United States of America.
  • Loader MC; Infectious Diseases & Immunity and the Wellcome Trust-Imperial Centre for Global Health, Imperial College London, London, England, United Kingdom.
  • Verastegui MR; Department of Microbiology, School of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Sterling C; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, United States of America.
  • Friedland JS; Infectious Diseases & Immunity and the Wellcome Trust-Imperial Centre for Global Health, Imperial College London, London, England, United Kingdom.
  • Garcia HH; Department of Microbiology, School of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Gilman RH; Asociación Benéfica Proyectos en Informática, Salud, Medicina y Agricultura (AB PRISMA), Lima, Peru; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, United States of America.
PLoS One ; 9(12): e113239, 2014.
Article en En | MEDLINE | ID: mdl-25469506
BACKGROUND: Neurocysticercosis is a leading cause of seizures and epilepsy in most of the world, and it occurs when Taenia solium larval cysts infect the central nervous system. T. solium tapeworm infection is endemic in much of Peru, but there are scarce data on the prevalence in many rural highland communities where it is likely to be hyper-endemic. Peace Corps Volunteers live and work in these communities; however, to our knowledge, they have not been used to facilitate public health research. MATERIALS AND METHODS: We utilized Peace Corps Volunteers to estimate the prevalence of T. solium tapeworm infection in seven rural communities in northern Peru. A convenience non-random sampling frame was used. Peace Corps Volunteers facilitated the collection of stool samples (N = 2,328), which were analyzed by sedimentation and microscopy. Niclosamide treatment and purgation preceded species identification, which was done by PCR-REA. RESULTS: Taenia sp. egg-positive stool samples were found in three of the seven communities we surveyed. The overall prevalence of Taenia sp. egg positivity was 2.1% (49/2,328) (95% CI = 1.6-2.8%) with prevalence up to 4.3% (42/977) (95% CI = 3.1-5.8%) by community. All 34 of the specimens tested by PCR-REA were T. solium. The overall prevalence of T. solium tapeworm infection was 1.5% (34/2,328) (95% CI = 1.0-2.0%). Prevalence up to 2.9% (28/977) (95% CI = 1.9-4.1%) by community was observed. CONCLUSION/SIGNIFICANCE: This study recorded high T. solium tapeworm prevalence, and identified hyper-endemic rural communities. It demonstrates that synergy between researchers and Peace Corps Volunteers can be an effective means to conducting large-scale, community-based studies in remote areas of Peru.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurocisticercosis / Taenia solium / Anticestodos / Niclosamida Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male País/Región como asunto: America do norte / America do sul / Peru Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurocisticercosis / Taenia solium / Anticestodos / Niclosamida Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male País/Región como asunto: America do norte / America do sul / Peru Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos