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Global profiling of protein lipidation using chemical proteomic technologies.
Tate, Edward W; Kalesh, Karunakaran A; Lanyon-Hogg, Thomas; Storck, Elisabeth M; Thinon, Emmanuelle.
Afiliación
  • Tate EW; Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK. Electronic address: e.tate@imperial.ac.uk.
  • Kalesh KA; Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
  • Lanyon-Hogg T; Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
  • Storck EM; Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
  • Thinon E; The Rockefeller University, 1230 York Avenue, New York, USA.
Curr Opin Chem Biol ; 24: 48-57, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25461723
Protein lipidation is unique amongst post-translational modifications (PTMs) in enabling direct interaction with cell membranes, and is found in every form of life. Lipidation is important in normal function and in disease, but its intricate interplay with disease context presents a challenging for drug development. Global whole-proteome profiling of protein lipidation lies beyond the range of standard methods, but is well-suited to metabolic tagging with small 'clickable' chemical reporters that do not disrupt metabolism and function; chemoselective reactions are then used to add multifunctional labels exclusively to tagged-lipidated proteins. This chemical proteomic technology has opened up the first quantitative whole-proteome studies of the known major classes of protein lipidation, and the first insights into their full scope in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Procesamiento Proteico-Postraduccional Límite: Animals / Humans Idioma: En Revista: Curr Opin Chem Biol Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Procesamiento Proteico-Postraduccional Límite: Animals / Humans Idioma: En Revista: Curr Opin Chem Biol Asunto de la revista: BIOQUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido