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Effect of periprocedural amiodarone on procedure outcome in patients with longstanding persistent atrial fibrillation undergoing extended pulmonary vein antrum isolation: results from a randomized study (SPECULATE).
Mohanty, Sanghamitra; Di Biase, Luigi; Mohanty, Prasant; Trivedi, Chintan; Santangeli, Pasquale; Bai, Rong; Burkhardt, John David; Gallinghouse, Joseph G; Horton, Rodney; Sanchez, Javier E; Hranitzky, Patrick M; Zagrodzky, Jason; Al-Ahmad, Amin; Pelargonio, Gemma; Lakkireddy, Dhanunjay; Reddy, Madhu; Forleo, Giovanni; Rossillo, Antonio; Themistoclakis, Sakis; Hongo, Richard; Beheiry, Salzwa; Casella, Michela; Dello Russo, Antonio; Tondo, Claudio; Natale, Andrea.
Afiliación
  • Mohanty S; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Di Biase L; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas; Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas; Albert Einstein College of Medicine at Montefiore Hospital, Bronx, New York; University of Foggia, Foggia, Italy.
  • Mohanty P; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Trivedi C; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Santangeli P; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas; University of Foggia, Foggia, Italy; University of Pennsylvania, Philadelphia, Pennsylvania.
  • Bai R; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas; Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Burkhardt JD; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Gallinghouse JG; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Horton R; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas; Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas.
  • Sanchez JE; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Hranitzky PM; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Zagrodzky J; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Al-Ahmad A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas.
  • Pelargonio G; Catholic University, Rome, Italy.
  • Lakkireddy D; University of Kansas, Kansas City, Kansas.
  • Reddy M; University of Kansas, Kansas City, Kansas.
  • Forleo G; University Tor Vergata, Rome, Italy.
  • Rossillo A; Ospedale dell'Angelo, Mestre/Venice, Italy.
  • Themistoclakis S; Ospedale dell'Angelo, Mestre/Venice, Italy.
  • Hongo R; California Pacific Medical Center, San Francisco, California.
  • Beheiry S; California Pacific Medical Center, San Francisco, California.
  • Casella M; RCCS Monzino Hospital, Milan, Italy.
  • Dello Russo A; RCCS Monzino Hospital, Milan, Italy.
  • Tondo C; RCCS Monzino Hospital, Milan, Italy.
  • Natale A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas; Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas; California Pacific Medical Center, San Francisco, California; Division of Cardiology, Stanford University, Palo Alto, California; Interve
Heart Rhythm ; 12(3): 477-483, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25460855
BACKGROUND: The impact of amiodarone on ablation outcome in longstanding persistent atrial fibrillation (LSPAF) patients is not known yet. OBJECTIVE: The purpose of this study was to assess the effect of amiodarone on procedural-outcomes in LSPAF patients undergoing catheter ablation. METHODS: We enrolled 112 LSPAF patients on amiodarone and scheduled to undergo atrial fibrillation (AF) ablation. Patients were randomized to amiodarone discontinuation 4 months before ablation (group 1, n = 56) and a control group (group 2, n = 56) in which ablation was performed without amiodarone discontinuation. All patients underwent pulmonary vein (PV) antrum and posterior wall isolation, defragmentation and extra PV triggers ablation. Patients were followed up for recurrence for 32 ± 8 months post-ablation. Repeat procedures in all recurrent patients were performed off amiodarone. RESULTS: During ablation, AF termination was more frequent in group 2 compared to group 1 [44 (79%) vs 32 (57%), P = .015]. After high-dosage isoproterenol, more non-PV triggers were disclosed in group 1 compared to group 2 (42 [75%] vs 24 [43%] respectively, P <.001). Group 2 had lower procedure, radiofrequency and fluoroscopy times compared to group 1 (2.7 ± 1 vs 3.1 ± 1 h, 69 ± 13 min vs 87 ± 11 min and 64 ± 14 min vs 85 ± 18 min respectively, p < .05). At 32 ± 8 month follow-up, on or off antiarrhythmic drug success rate was 37 (66%) in group 1 and 27 (48%) in group 2 (P = .04). During redo, new non-PV trigger sites were identified in group 2 patients. CONCLUSION: Periprocedural continuous amiodarone was associated with higher organization rate and lower radiofrequency ablation rate. However, masking non-PV triggers increased the late recurrence rate.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venas Pulmonares / Fibrilación Atrial / Ablación por Catéter / Amiodarona / Antiarrítmicos Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Rhythm Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venas Pulmonares / Fibrilación Atrial / Ablación por Catéter / Amiodarona / Antiarrítmicos Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Rhythm Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos