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Molecular epidemiology of Aspergillus collected from cystic fibrosis patients.
Sabino, Raquel; Ferreira, Jose A G; Moss, Richard B; Valente, Joana; Veríssimo, Cristina; Carolino, Elisabete; Clemons, Karl V; Everson, Cassie; Banaei, Niaz; Penner, John; Stevens, David A.
Afiliación
  • Sabino R; National Institute of Health Dr. Ricardo Jorge-Infectious Diseases Department, Lisbon, Portugal; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States; California Institute for Medical Research, San Jose, CA, United States.
  • Ferreira JA; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States; California Institute for Medical Research, San Jose, CA, United States; School of Medicine, Faculdade da Saúde e Ecologia Humana-FASEH, Vespasiano, Brazil.
  • Moss RB; Department of Pediatrics, Division of Pulmonology, Stanford University, Stanford, CA, United States.
  • Valente J; National Institute of Health Dr. Ricardo Jorge-Infectious Diseases Department, Lisbon, Portugal.
  • Veríssimo C; National Institute of Health Dr. Ricardo Jorge-Infectious Diseases Department, Lisbon, Portugal.
  • Carolino E; Scientific Area of Mathematics, Lisbon School of Health Technology, Polytechnic Institute of Lisbon, Lisbon, Portugal.
  • Clemons KV; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States; California Institute for Medical Research, San Jose, CA, United States.
  • Everson C; Department of Pediatrics, Division of Pulmonology, Stanford University, Stanford, CA, United States.
  • Banaei N; Clinical Microbiology Laboratory, Stanford University, Stanford, CA, United States.
  • Penner J; California Institute for Medical Research, San Jose, CA, United States.
  • Stevens DA; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, United States; California Institute for Medical Research, San Jose, CA, United States.
J Cyst Fibros ; 14(4): 474-81, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25459562
BACKGROUND: Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function and allergic disease. METHODS: Fifty-three Aspergillus isolates recovered from CF patients were identified to species by Internal Transcribed Spacer Region (ITS), ß-tubulin, and calmodulin sequencing. RESULTS: Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found. CONCLUSIONS: To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A. fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic approach geared to this pathogen.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergillus / Fibrosis Quística / Aspergilosis Pulmonar Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Cyst Fibros Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspergillus / Fibrosis Quística / Aspergilosis Pulmonar Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: J Cyst Fibros Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos