Effects of non-steroidal anti-inflammatory drugs on isolated human polymorphonuclear leukocytes (PMN): chemotaxis, superoxide production, degranulation and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) receptor binding.
Gen Pharmacol
; 20(3): 329-34, 1989.
Article
en En
| MEDLINE
| ID: mdl-2545509
1. We have examined the effects of tolmetin and meclofenamate on isolated human PMN functions under FMLP stimulating conditions. 2. In a dose dependent manner, tolmetin and meclofenamate inhibited all PMN functions, except that tolmetin stimulated PMN chemotaxis. 3. Meclofenamate was much more potent than tolmetin as an inhibitory agent. 4. We also conducted competitive receptor binding assays for tolmetin, meclofenamate and ibuprofen on the FMLP receptor. 5. All three NSAID inhibited FMLP binding in a dose dependent manner with the potency order being meclofenamate greater than ibuprofen greater than tolmetin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Antiinflamatorios no Esteroideos
/
N-Formilmetionina Leucil-Fenilalanina
/
Neutrófilos
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Gen Pharmacol
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Reino Unido