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CREB regulates memory allocation in the insular cortex.
Sano, Yoshitake; Shobe, Justin L; Zhou, Miou; Huang, Shan; Shuman, Tristan; Cai, Denise J; Golshani, Peyman; Kamata, Masakazu; Silva, Alcino J.
Afiliación
  • Sano Y; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Shobe JL; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Zhou M; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Huang S; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Shuman T; Department of Neurology at David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Cai DJ; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Golshani P; Department of Neurology at David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Kamata M; Department of Hematology and Oncology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Silva AJ; Departments of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: silvaa@mednet.ucla.edu.
Curr Biol ; 24(23): 2833-7, 2014 Dec 01.
Article en En | MEDLINE | ID: mdl-25454591
The molecular and cellular mechanisms of memory storage have attracted a great deal of attention. By comparison, little is known about memory allocation, the process that determines which specific neurons in a neural network will store a given memory. Previous studies demonstrated that memory allocation is not random in the amygdala; these studies showed that amygdala neurons with higher levels of the cyclic-AMP-response-element-binding protein (CREB) are more likely to be recruited into encoding and storing fear memory. To determine whether specific mechanisms also regulate memory allocation in other brain regions and whether CREB also has a role in this process, we studied insular cortical memory representations for conditioned taste aversion (CTA). In this task, an animal learns to associate a taste (conditioned stimulus [CS]) with the experience of malaise (such as that induced by LiCl; unconditioned stimulus [US]). The insular cortex is required for CTA memory formation and retrieval. CTA learning activates a subpopulation of neurons in this structure, and the insular cortex and the basolateral amygdala (BLA) interact during CTA formation. Here, we used a combination of approaches, including viral vector transfections of insular cortex, arc fluorescence in situ hybridization (FISH), and designer receptors exclusively activated by designer drugs (DREADD) system, to show that CREB levels determine which insular cortical neurons go on to encode a given conditioned taste memory.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Memoria Límite: Animals / Humans Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Memoria Límite: Animals / Humans Idioma: En Revista: Curr Biol Asunto de la revista: BIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido