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Alterations of natural killer cells in traumatic brain injury.
Kong, Xiao-Dong; Bai, Sheng; Chen, Xin; Wei, Hui-Jie; Jin, Wei-Na; Li, Min-Shu; Yan, Yaping; Shi, Fu-Dong.
Afiliación
  • Kong XD; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Bai S; Department of Geriatrics, Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Chen X; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Wei HJ; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Jin WN; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Li MS; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Yan Y; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Shi FD; Departments of Neurology and Neurosurgery, Key Laboratory of Post-trauma Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Neurosci Bull ; 30(6): 903-912, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25446874
To investigate the relationship between natural killer (NK) cells and traumatic brain injury (TBI), we tracked an established phenotype of circulating NK cells at several time points in patients with different grades of TBI. In serial peripheral blood samples, NK cells were prospectively measured by flow cytometry of CD3(-) CD56(+) lymphocytes. Compared to healthy controls, TBI patients had reductions in both the percentage and the absolute number of NK cells. Furthermore, the magnitude of NK cell reduction correlated with the degree of TBI severity at several time points. That is, NK cell population size was independently associated with lower Glasgow Coma Scale scores. In addition, at some time points, a positive correlation was found between the NK cell counts and Glasgow Outcome Scale scores. Our results indicate that TBI induces a reduction in the number of NK cells, and the magnitude of the reduction appears to parallel the severity of TBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Células Asesinas Naturales Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Células Asesinas Naturales Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur