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Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity.
Jenson, Daniel; Yang, Kechun; Acevedo-Rodriguez, Alexandra; Levine, Amber; Broussard, John I; Tang, Jianrong; Dani, John A.
Afiliación
  • Jenson D; Department of Neuroscience, Center on Addiction, Learning, Memory, Baylor College of Medicine, Houston, TX 77030, USA.
  • Yang K; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, Philadelphia, PA 19104, USA.
  • Acevedo-Rodriguez A; Department of Neuroscience, Center on Addiction, Learning, Memory, Baylor College of Medicine, Houston, TX 77030, USA.
  • Levine A; Department of Neuroscience, Center on Addiction, Learning, Memory, Baylor College of Medicine, Houston, TX 77030, USA.
  • Broussard JI; Department of Neuroscience, Center on Addiction, Learning, Memory, Baylor College of Medicine, Houston, TX 77030, USA.
  • Tang J; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
  • Dani JA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address: johndani@upenn.edu.
Neuropharmacology ; 90: 23-32, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25445492
Attention-deficit hyperactive disorder (ADHD) is the most commonly studied and diagnosed psychiatric disorder in children. Methylphenidate (MPH, e.g., Ritalin) has been used to treat ADHD for over 50 years. It is the most commonly prescribed treatment for ADHD, and in the past decade it was the drug most commonly prescribed to teenagers. In addition, MPH has become one of the most widely abused drugs on college campuses. In this study, we examined the effects of MPH on hippocampal synaptic plasticity, which serves as a measurable quantification of memory mechanisms. Field potentials were recorded with permanently implanted electrodes in freely-moving mice to quantify MPH modulation of perforant path synaptic transmission onto granule cells of the dentate gyrus. Our hypothesis was that MPH affects hippocampal synaptic plasticity underlying learning because MPH boosts catecholamine signaling by blocking the dopamine and norepinephrine transporters (DAT and NET respectively). In vitro hippocampal slice experiments indicated MPH enhances perforant path plasticity, and this MPH enhancement arose from action via D1-type dopamine receptors and ß-type adrenergic receptors. Similarly, MPH boosted in vivo initiation of long-term potentiation (LTP). While there was an effect via both dopamine and adrenergic receptors in vivo, LTP induction was more dependent on the MPH-induced action via D1-type dopamine receptors. Under biologically reasonable experimental conditions, MPH enhances hippocampal synaptic plasticity via catecholamine receptors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos / Receptores Dopaminérgicos / Potenciación a Largo Plazo / Giro Dentado / Estimulantes del Sistema Nervioso Central / Metilfenidato Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Adrenérgicos / Receptores Dopaminérgicos / Potenciación a Largo Plazo / Giro Dentado / Estimulantes del Sistema Nervioso Central / Metilfenidato Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido